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Anti Thyroperoxidase Antibody

Anti Thyroperoxidase Antibody

Also referred as
Anti Microsomal Antibody (AMA)
For men & women
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Thyroid peroxidase (TPO)antibody test measures anti thyroperoxidase antibodies in your blood. The body produces these antibodies when cells in your thyroid become damaged. These antibodies can be a sign of autoimmune diseases that cause the thyroid to make too much or little thyroid hormone.

Having antithyroid antibodies in your blood doesn’t automatically mean you have a thyroid disease. However, you may be at an increased risk for thyroid disease in the future. If your test is positive, it means that antibodies are present in your blood which could indicate that there is an autoimmune condition affecting your thyroid gland.

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What does Anti Thyroperoxidase Antibody measure?

TPO is also known as thyroid peroxidase or iodide peroxidase which is an enzyme mainly expressed in the thyroid gland. The thyroid gland is positioned at the lower part of the neck. TPO is found in the cells of the thyroid follicle where it helps in the production of the thyroid hormones. Its basic function is to oxidize iodide ions to form iodine atoms which assist in the production of thyroxine (T4) or triiodothyronine (T3), the thyroid hormones. TPO is an antigenic determinant of autoantibodies in diseases like autoimmune disorders of the thyroid. These antibodies are called as anti-TPO antibodies (anti-Thyroid peroxidase antibodies) which activates complement and might be associated with dysfunction of thyroid and its pathogenesis. To assess these antibodies, Anti-TPO antibody test is carried out.

FAQs related to Anti Thyroperoxidase Antibody

Hypothyroidism, also called underactive thyroid or low thyroid is a condition in which the thyroid gland does not produce enough thyroid hormones. It can be commonly caused by intake of low iodine diet or Hashimoto's thyroiditis (an autoimmune disease). Less common causes include previous treatment with radioactive iodine, injury to the pituitary gland which secretes TSH, intake of certain medicines, previous thyroid surgery, or a lack of a functioning thyroid gland at birth.
There is no risk associated with the test. However, since this test involves a needle prick to withdraw the blood sample, in very rare cases, a patient may experience increased bleeding, hematoma formation (blood collection under the skin), bruising or infection at the site of needle prick.
No, there is no special preparation required for the test.
It is an enzyme which is produced by the thyroid gland and it plays an important role in the production of thyroid hormones. Sometimes, antibodies are formed against this enzyme for which Anti TPO antibody test is required.
An autoimmune disorder is a condition when your body’s immune system starts to attack parts of the body such as joints or skin mistaking it for foreign bodies. Autoantibodies start to release in the body which attacks the healthy cells.
The risk factor includes family history, obesity, smoking, blood pressure medications, cholesterol lowering medications and antibiotics.
It is an autoimmune disease where the body’s immune system attacks the thyroid gland. This condition leads to hypothyroidism in which the thyroid gland starts to produce fewer thyroid hormones. A person having a family history of Hashimoto’s thyroiditis or taking too much iodine or getting exposed to radiation fall under the risk of having Hashimoto’s thyroiditis. The symptoms include weight gain, fatigue, paleness or puffiness of the face, joint and muscle pain, constipation, joint and muscle pain, thinning or loss of hair, slowed heart rate, depression, irregular or heavy menstrual periods.
It is an early form of hypothyroidism in which sufficient thyroid hormones are not produced by the thyroid gland. It can be seen in persons who have a family history of autoimmune disorders of thyroid or injury to thyroid or use of radioactive iodine therapy or with the use of medications containing iodine or lithium. The symptoms include fatigue, depression, constipation, weight gain, goiter, hair loss, intolerance to cold.
If the Anti TPO test results are not in the normal range, your doctor may ask for the following tests: Thyroid Hormone Binding Globulin (TBG) Thyroid profile
Content created by
Written by:
Dr. Lipika Khurana
BDS, PGDHHM
Reviewed by:
Dr. Swati Gupta (Anand)
MBBS, MD Lab Medicine
Want to know moreRead our editorial policy
Last Updated17th Mar 2026

Anti Thyroperoxidase Antibody test price for other cities

Price inAhmedabadRs. 800
Price inAllahabadRs. 800
Price inAmritsarRs. 800
Price inBangaloreRs. 750
Price inBhopalRs. 800

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Contains 1 test
Anti Thyroperoxidase Antibody