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Human Leukocyte Antigen B27

Human Leukocyte Antigen B27

Also referred as
HLA B27 PCR
For men & women
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HLA B-27, also called Human leukocyte antigen B-27, is a blood test indicated to look for a protein (HLA B-27), present on the surface of white blood cells. Presence of HLA B-27 may indicate a possibility of autoimmune disease, where the guarding cells (WBC) attacks own cells.

This test is done if one experiences symptoms of arthritis such as chronic joint pain, stiffness, and inflammation in the lower back. It may also be advised in case of inflammation of the eyes, especially in males.

People with HLA B-27 have increased chances of developing autoimmune diseases like rheumatoid arthritis and reactive arthritis. B-27 is also said to be linked with inflammatory bowel disease and other chronic conditions. 

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What does Human Leukocyte Antigen B27 measure?

HLA B-27 test determines the presence or absence of human leukocyte antigen which is present on the surface of white blood cells. The HLA B-27 also refers to the gene which codes for the HLA B-27 protein. 


HLA B-27 are proteins that help the immune system to differentiate the body’s own cells from other foreign cells. Every person has an inherited combination of HLA genes which codes for many antigens that are present on the surfaces of their cells. This HLA combination is distinctive for each person and is based on the presence or absence of each antigen.


People with HLA B-27 have increased chances of developing autoimmune diseases like ankylosing spondylitis, rheumatoid arthritis, reactive arthritis, and isolated acute anterior uveitis. HLA B-27 is also said to be linked with inflammatory bowel disease and other chronic conditions.


FAQs related to Human Leukocyte Antigen B27

The healthcare provider takes a blood sample from the arm. The site from where the blood is to be withdrawn is cleaned with a swab of rubbing alcohol. This is then followed by inserting a small needle which has a tube attached to it for collecting blood. Once the sufficient blood for analysis is withdrawn, the needle is removed. The site is then covered with a gauze pad.
As such there is no risk but in few cases, bruising, bleeding, and infection at the puncture site can be seen. In very few cases, there can be swelling of the vein after the blood is withdrawn.
Reactive arthritis is a painful form of inflammatory arthritis. This includes joint disease caused due to inflammation. It develops due to inflammation caused in response to infection which is caused by certain bacteria which are present in genitals (Chlamydia trachomatis) or the bowel (Campylobacter, Shigella, Salmonella, and Yersinia).
Ankylosing spondylitis is a form of arthritis that primarily affects the spine, but can affect other joints as well. It comprises of vertebrae (spinal joints) inflammation which can further cause severe, chronic pain and discomfort. If the inflammation is left unchecked, it can lead to new bone formation in the spine which is known as ankylosis. In ankylosis, sections of the spine fuse in a fixed and immobile position. In this, one can develop inflammation, pain and stiffness in other parts of the body such as hips, ribs, shoulders, heels, and small joints of hands and feet. The inflammation can also involve eyes, the condition is known as uveitis or iritis. Whereas, in rare cases, heart, and lungs can be affected.
Content created by
Written by:
Dr. Lipika Khurana
BDS, PGDHHM
Reviewed by:
Dr. Swati Gupta (Anand)
MBBS, MD Lab Medicine
Want to know moreRead our editorial policy
Last Updated17th Mar 2026

Human Leukocyte Antigen B27 test price for other cities

Price inAgraRs. 2887
Price inAhmedabadRs. 2572
Price inAllahabadRs. 2572
Price inAmritsarRs. 2572
Price inBangaloreRs. 2572

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Contains 1 test
Human Leukocyte Antigen B27