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Adcapone Tablet

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Khushbu Goel, DM, MD
Last updated on 12 Nov 2024 | 01:00 AM (IST)
Adcapone Tablet is used in the treatment of Parkinson's disease. It helps to treat wearing-off symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control.
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General Information

Contains

Entacapone (200mg)

Marketer

Sun Pharmaceutical Industries Ltd

Storage

Store below 30°C
The content is shown in English
Adcapone Tablet image
Adcapone Tablet image
Adcapone Tablet image

Product introduction

Adcapone Tablet is usually used in combination with carbidopa/levodopa. It may be taken with or without food, preferably at bedtime. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor.

If you have missed a dose, take it as soon as you remember it. This medication mustn't be stopped suddenly without talking to the doctor as it may worsen your condition. Your doctor may advise for periodic skin examination as it can cause melanoma.

Some common side effects of this medicine include nausea, vomiting, fatigue, confusion, constipation, insomnia (difficulty sleeping), nightmares, and increased sweating. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. It is common to have diarrhea with this medicine, so drink plenty of fluids and watch for weight loss. Inform your doctor if you develop any unusual changes in mood, an abnormally high sex drive, and hallucinations. It may cause your urine to change in a brownish-orange color but it is not harmful and usually resolves once treatment is completed. Please consult your doctor if these side effects worry you or do not go away.

Uses of Adcapone Tablet

Benefits of Adcapone Tablet

Parkinson's disease
Adcapone Tablet is one of the most effective medications to relieve symptoms of Parkinson's disease such as tremors, muscle stiffness and difficulty moving. It increases the amount of a chemical called dopamine in the brain which helps in the coordination of body movements. This medicine can therefore enhance the quality of life by improving the ability to carry out daily functions in a better manner.

Side effects of Adcapone Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Adcapone
  • Nausea
  • Vomiting
  • Fatigue
  • Confusion
  • Constipation
  • Insomnia (difficulty in sleeping)
  • Nightmares
  • Hallucination
  • Dizziness
  • Diarrhea
  • Muscle coordination impaired
  • Abdominal pain
  • Dryness in mouth

How to use Adcapone Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Adcapone Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Adcapone Tablet works

Adcapone Tablet is a selective reversible inhibitor that is given in combination with levodopa. It works by inhibiting a chemical messenger [catechol-O-methyl transferase (COMT)] which in turn helps in increasing the amount of dopamine (chemical messenger) in the brain. Thus, an adequate amount of dopamine in the brain helps to coordinate body movements.

All substitutes for Adcapone Tablet

For information purposes only. Consult a doctor before taking any medicine.

Entacom Tablet

by Intas Pharmaceuticals Ltd
₹6.79/tablet
20% cheaper
<h3 class=bodySemiBold>Entacom Tablet</h3>

Adcopas 200mg Tablet

by Eris Lifesciences Ltd
₹7/tablet
18% cheaper
<h3 class=bodySemiBold>Adcopas 200mg Tablet</h3>

Quick tips

  • You have been prescribed Adcapone Tablet to enhance the effectiveness of levodopa for the treatment of Parkinson's disease.
  • It can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Inform your doctor if you develop impulsive, unusual behavior and/or an abnormally high sex drive.
  • Talk to your doctor in case you develop hallucinations or other changes in your behavior.
  • It is common to have diarrhea with this drug. Therefore, drink plenty of fluids and watch for weight loss.
  • Do not get worried if you notice a reddish-brown discoloration in your urine as it is harmless in nature.
  • Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

Alcohol

UNSAFE
Adcapone Tablet may cause excessive drowsiness with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Adcapone Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Adcapone Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving

Driving

CAUTION
Adcapone Tablet may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
Kidney

Kidney

SAFE IF PRESCRIBED
Adcapone Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Adcapone Tablet may not be needed in these patients. Please consult your doctor.
Liver

Liver

UNSAFE
Adcapone Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
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Frequently asked questions

No, Adcapone Tablet should not be crushed or split. Take it as a whole with a full glass of water at the same time as you take a dose of levodopa
Yes, Adcapone Tablet may cause your urine to change to a brownish-orange color. This effect is common and is not harmful.
The combined use of Adcapone Tablet and levodopa has been associated with cases of excessive daytime sleepiness and sudden sleep onset episodes. If you experience these symptoms, then you should neither drive nor operate other complex machinery. Consult your doctor if it becomes troublesome.
In impulse control disorders, you may get urges or cravings to behave in ways that are unusual for you. In such disorders, you cannot resist the impulse, drive or temptation to carry out certain activities that could harm yourself or others. Additionally, it may include addictive gambling, excessive eating or spending, an abnormally high sex drive or a preoccupation with an increase in sexual thoughts or feelings. In such a case, your doctor may suggest dose reduction or discontinuation of dose.
In case you take more than the recommended doses of Adcapone Tablet, you may experience confusion, decreased activity, sleepiness, decreased muscle tone, skin discoloration, and urticaria. If any such symptoms occur, you should seek immediate medical attention in a nearby hospital or contact your doctor.
No, Adcapone Tablet does not cross the blood-brain barrier. It is useful in prolonging the duration of the benefit obtained from individual doses of levodopa.
No, Adcapone Tablet does not affect fertility. However, it should be avoided by pregnant and lactating women because there is no sufficient data to support the safety of this patient group.
No, it is not a dopamine agonist. Adcapone Tablet is a selective and reversible inhibitor of COMT (catechol-O-methyltransferase) which works by increasing and maintaining sustained levels of levodopa when levodopa is given along with it.

Fact Box

Chemical Class

Hydroxycinnamic Acids Derivatives

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

COMT inhibitors

References

  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 473-74.
  2. Entacapone. Espoo, Finland: Orion Corporation; 2000 [revised Jun. 2014]. [Accessed 25 Mar. 2019] (online) Available from:
  3. Entacapone. Newbury, Berkshire: Orion Pharma (UK) Limited; 1998 [revised 15 Dec. 2016]. [Accessed 28 Jan. 2019] (online) Available from:
  4. Merello M, Lees AJ, Webster R, et al. Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 1994;57(2):186-89. [Accessed 19 Jun. 2019] (online) Available from:
  5. Entacapone. North Ryde, New South Wales: Novartis Pharmaceuticals Australia Pty Limited; 2013. [Accessed 19 Jun. 2019] (online) Available from:
  6. MedlinePlus. Entacapone. [Accessed on 25 Mar. 2019] (online) Available from:
  7. Entacapone [Prescribing Information]. East Hanover, N.J: Novartis Pharmaceuticals Corporation; 2020. [Accessed 25 Jul. 2024] (online) Available from:
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Patient concerns

Parkinson's disease tremors ,Insomnia.

Dr. Ravi Shankar M.
Dr. Ravi Shankar M.
Ayurveda
Use Dhanadanayanadi kashayam 15ml twice a day with 15 ml water before food and Zandopa 10 grams twice a day witk milk after food and Tab Dhanvantari Vati 1-0-1 after food for 2 months

Parkinson's disease for 25 yrs. Taking allopathy Suggestions needed

Dr. Deepak Kumar Soni
Dr. Deepak Kumar Soni
Ayurveda
Kindly consult to any good Ayuvedic Panchkarma center. Panchkarma therapy will give you some result .
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sun Pharmaceutical Industries Ltd
Address: Plot no 107/108,Namli block , Ranipool, East Sikkim 737135

Vendor Details

Country of origin: India

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