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Amitryp-Plus Tablet

Written By Dr. Saleh Rifai, BCMAS, Pharm.D
Reviewed By Dr. Ashish Ranjan, MD (Pharmacology), MBBS
Last updated on 12 Nov 2024 | 01:05 AM (IST)
Amitryp-Plus Tablet is a combination of two medicines. It is used in the treatment of depression associated with anxiety. It helps in regulating mood and to reduce anxiety.
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General Information

Contains

Amitriptyline (12.5mg)+ Chlordiazepoxide (5mg)

Marketer

Biologic Psychotropics India Pvt Ltd

Storage

Store below 30°C
The content is shown in English
Amitryp-Plus Tablet image

Product introduction

Amitryp-Plus Tablet is taken with or without food. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. In case you miss a dose of this medicine, take it as soon as you remember. Never skip any dose and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may worsen your symptoms. Taking this medicine for a long time may require regular monitoring of blood and liver functions.

Some common side effects of this medicine include constipation, difficulty in urination, weight gain, confusion, orthostatic hypotension (sudden lowering of blood pressure on standing). This medicine may cause weight loss. In case of losing weight, consult a dietitian for dietary supplements or try to increase your food portion. Most of the common side effects tend to be mild. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects are rare. Remember to inform your doctor if you develop any unusual changes in mood as it may lead to suicidal thoughts.

Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Uses of Amitryp-Plus Tablet

Benefits of Amitryp-Plus Tablet

Treatment of Depression
Amitryp-Plus Tablet works by affecting the balance of certain chemicals (such as serotonin) in the brain. It helps improve mood and feelings of wellbeing, relieve anxiety and tension, helps you sleep better, and increase your energy level. It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly.

Side effects of Amitryp-Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Amitryp-Plus
  • Constipation
  • Difficulty in urination
  • Weight gain
  • Confusion
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Tiredness
  • Blurred vision
  • Dryness in mouth
  • Increased heart rate
  • Uncoordinated body movements
  • Depression
  • Memory impairment

How to use Amitryp-Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Amitryp-Plus Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Amitryp-Plus Tablet works

Amitryp-Plus Tablet is a combination of two medicines:.

Quick tips

  • Amitryp-Plus Tablet is prescribed for the treatment of depression.
  • It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
  • Do not stop taking Amitryp-Plus Tablet unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
  • Inform your doctor if you are taking any other antidepressants.
  • Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
  • Avoid alcohol while taking Amitryp-Plus Tablet.
  • If you have diabetes, you will be asked to monitor your blood glucose level regularly as Amitryp-Plus Tablet may affect the levels of sugar in your blood.
  • Amitryp-Plus Tablet is prescribed for the treatment of depression.
  • It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
  • Do not stop taking Amitryp-Plus Tablet unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
  • Inform your doctor if you are taking any other antidepressants.
  • Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
  • Avoid alcohol while taking Amitryp-Plus Tablet.
  • If you have diabetes, you will be asked to monitor your blood glucose level regularly as Amitryp-Plus Tablet may affect the levels of sugar in your blood.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Amitryp-Plus Tablet.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Amitryp-Plus Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Amitryp-Plus Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving

Driving

UNSAFE
Amitryp-Plus Tablet may cause side effects which could affect your ability to drive.
As Amitryp-Plus Tablet may make you feel drowsy or affect your concentration and this may affect your ability to drive.
Kidney

Kidney

SAFE IF PRESCRIBED
Amitryp-Plus Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Amitryp-Plus Tablet may not be needed in these patients. Please consult your doctor.
Liver

Liver

CAUTION
Amitryp-Plus Tablet should be used with caution in patients with liver disease. Dose adjustment of Amitryp-Plus Tablet may be needed. Please consult your doctor.
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Frequently asked questions

During the first few months of treatment, Amitryp-Plus Tablet may increase suicidal thoughts or actions in some patients. Patients having mood or behavioral disorder have a high risk of developing suicidal thoughts and actions. You should pay close attention and report your doctor of any such behavior or mood changes. Make sure that you visit the doctor for the scheduled follow-up appointments.
No, you should continue to take Amitryp-Plus Tablet, even if you feel well. If you stop Amitryp-Plus Tablet suddenly, serious withdrawal symptoms may occur. Consult your doctor if the symptoms are relieved, he might decrease your dose gradually.
There are reports which suggest that the use of Amitryp-Plus Tablet can cause weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight. An important to remember is that it is easier to prevent weight gain than losing increased weight.
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Yes, Amitryp-Plus Tablet can make you feel sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities till you know how this medicine affects you.
The use of Amitryp-Plus Tablet can affect the sexual life of both men and women. Most commonly caused problems are decreased sexual desire, erectile dysfunction (inability to develop or maintain erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort while having sex. If you experience these problems, discuss with your doctor.
No, do not drink alcohol while you are taking Amitryp-Plus Tablet. Drinking alcohol can increase the severity of drowsiness or sleepiness caused by Amitryp-Plus Tablet.
Yes, Amitryp-Plus Tablet can the change the color of the urine to blue or green. This change of color is expected while using Amitryp-Plus Tablet, and it is not harmful. Your urine color becomes normal once you stop taking Amitryp-Plus Tablet.
Everybody responds differently to the treatment. In general, it can take several weeks to feel the full benefits of Amitryp-Plus Tablet, although some people will start to feel better sooner. When taking Amitryp-Plus Tablet, it is important to give it time to work.

Fact Box

Habit Forming

Yes

Therapeutic Class

NEURO CNS

References

  1. DailyMed. Chlordiazepoxide and amitriptyline hydrochloride. [Accessed 10 Apr. 2019] (online) Available from:
  2. MedlinePlus. Chlordiazepoxide. [Accessed 10 Apr. 2019] (online) Available from:
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Patient concerns

I had recently undergone left humerus plating surgery and i was told to take setfrac plus tablet The problem is setfrac plus tablet is not available in my town so can u please sugeat the substitute tablet to setfrac plus?????

Dr. Rohit Chakor
Dr. Rohit Chakor
Orthopaedics
You see the content of the tablet and ask for it

Can i take purtia tablet instead of purtia plus

Dr. Akshat Goel
Dr. Akshat Goel
Orthopaedics
Please refer to a General Physician
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Biologic Psychotropics India Pvt Ltd
Address: Near UCO Bank, Nahan Road, Kalaamb, Sirmaur-173030, Himachal Pradesh, India

Vendor Details

Country of origin: India

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