Amphotin 50mg

Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology

Last updated on 10 Nov 2024 | 01:11 AM (IST)

Amphotin 50mg is an antifungal medication. It is used in the treatment of severe fungal infections and kala-azar. It kills the infection causing fungi and thus, treats the infection.

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Stored between 2-8°C

₹290 MRP ₹2993% off

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General Information

Contains

Amphotericin B (50mg)

Marketer

United Biotech Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Amphotin 50mg is administered as an injection by a healthcare professional. Kindly do not self administer. Before you take this medicine, inform your doctor if you suffer from diabetes, liver/kidney problems or are on dialysis or have low potassium level in blood.

It may lead to a few common side effects like headache, vomiting, nausea, stomach cramps and fever. You may also notice some injection site reactions like pain, swelling or redness. Inform your doctor if these side effects persist for a longer duration. Please consult your doctor if you are pregnant, planning to conceive or breastfeeding.

Uses of Amphotin Injection

Severe fungal infections
Kala-azar

Benefits of Amphotin Injection

Severe fungal infections
Amphotin 50mg works by killing the fungi which can cause serious infections. It is given by a doctor or nurse and should not be self-administered. It usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all the fungi and yeast causing the infection are killed and do not become resistant.

Kala-azar
Kala azar is a disease caused by leishmania parasites mainly by the bite of infected sandflies. Amphotin 50mg helps to kill the infection causing parasites and helps to treat the infection. This medicine is given by a doctor or nurse and should not be self-administered. It usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all the parasites are killed and do not become resistant.

Side effects of Amphotin Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Amphotin

Injection site reactions (pain, swelling, redness)
Nausea
Vomiting
Chills
Headache
Anemia (low number of red blood cells)
Decreased potassium level in blood
Abnormal liver function tests
Decreased magnesium level in blood
Diarrhea
Decreased appetite
Hypotension (low blood pressure)
Skin rash
Nephrocalcinosis
Increased creatinine level in blood
Abnormal renal function tests
Renal tubular acidosis

How to use Amphotin Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Amphotin Injection works

Amphotin 50mg is an antifungal medication. It kills fungi by destroying the fungal cell membrane.

All substitutes for Amphotin 50mg

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

It is usually given as an injection over 1-2 hours under the supervision of a medical professional.
Amphotin 50mg can cause rash, chills, headache, and tiredness during initial days of the treatment, but these may fade away with time.
Your doctor may ask you for regular blood tests to monitor your blood sugar, potassium, magnesium and kidney function.
Inform your doctor immediately if you notice pain or blood upon urination, swelling of the face and trouble breathing.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Amphotin 50mg. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Amphotin 50mg is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

CONSULT YOUR DOCTOR

Amphotin 50mg is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Amphotin 50mg may cause side effects which could affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Amphotin 50mg is safe to use in patients with kidney disease. No dose adjustment of Amphotin 50mg is recommended.
However, inform your doctor if you have any underlying kidney disease.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Amphotin 50mg in patients with liver disease. Please consult your doctor.

Frequently asked questions

Is Amphotin 50mg fungistatic or fungicidal?

Amphotin 50mg is fungicidal in nature, it acts by killing the fungus

Is Amphotin 50mg light sensitive?

Amphotin 50mg is not light sensitive

What is Amphotin 50mg liposomal?

Liposomal Amphotin 50mg is a lipid-associated formulation. Liposomal encapsulation or incorporation into a lipid complex of Amphotin 50mg can substantially improves drug safety especially nephrotoxicity associated with the drug

Is Amphotin 50mg an antibiotic?

Yes, Amphotin 50mg is an antifungal antibiotic for the treatment of serious infections caused by fungi like fungal infections of one or more deep organs of the body, suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells [neutrophils]) and Visceral leishmaniasis (disease caused by a parasite)

Is Amphotin 50mg testing dose needed?

Yes, administration of Amphotin 50mg is associated with allergy (severe and serious allergic) reaction, therefore it is recommended to administer a test dose before starting the therapy to check for sensitivity

How is Amphotin 50mg administered?

Amphotin 50mg is either administered as intravenous injection or infusion by a registered medical professional only

How does Amphotin 50mg cause nephrotoxicity and hyperkalemia?

Amphotin 50mg can disrupt the lipid components of human kidney cells, thereby causing nephrotoxicity. The exact mechanism of hypokalemia is not known, but kidney damage may result in excessive loss of potassium in urine.

Fact Box

Chemical Class

Aminoglycosides {Polyenes}

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

Fungal cell membrane active agent

Related lab tests

Complete Blood Count

References

Phillips MA, Stanley SL Jr. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1424.
Bennett JE. Antifungal Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1571-75.
Sheppard D, Lampiris HW. Antifungal Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 836-38.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 68-69.
Medsacpe. Amphotericin. [Accessed 29 Mar. 2019] (online) Available from:
Amphotericin B. San Dimas, California: Gilead Sciences, Inc.; 2000. [Accessed 04 Feb. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. Jornal de Pediatria. 2004; 80(5):4-6. [Accessed 29 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 29 Mar. 2019] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: United Biotech Pvt Ltd
Address: FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Amphotin 50mg

General Information

Contains

Marketer

Storage

Product introduction

Uses of Amphotin Injection

Benefits of Amphotin Injection

Side effects of Amphotin Injection

How to use Amphotin Injection

How Amphotin Injection works

All substitutes for Amphotin 50mg

Amphotret 50mg Injection

Amfy 50mg Injection

Ampholip 50mg INJECTION

Amphotin Lip 50mg Injection

Affytericin-B Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

Is Amphotin 50mg fungistatic or fungicidal?

Is Amphotin 50mg light sensitive?

What is Amphotin 50mg liposomal?

Is Amphotin 50mg an antibiotic?

Is Amphotin 50mg testing dose needed?

How is Amphotin 50mg administered?

How does Amphotin 50mg cause nephrotoxicity and hyperkalemia?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

References

Related products

Shelcal 500 Calcium+Vitamin D3 Tablet | For Bones, Joints, Muscles Care | Supports Immunity | Daily Mineral Blend

Revital H Men Multivitamin with Calcium, Zinc & Ginseng for Immunity, Strong Bones & Energy

R.B Tone Syrup

Limcee Vitamin C Chewable Tablet | Flavour Orange

Similac Advance Stage 2 Follow-Up Formula (6 to 12 months)

Lupiheme Heme Iron Polypeptides Tablet

Mederma Skincare Scar Gel | For Scars Resulting from Injury, Burns, Surgery, Acne & Cut Marks | Derma Care

B Colen NS Syrup

Homochek Capsule with Folic Acid, Pyridoxine & Cyanocobalamin

Ensure Plus Powder Scientifically Formulated to Support Recovery Vanilla

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Have issue with the content

Disclaimer

Marketer details

Vendor Details

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