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Atrest 12.5 Tablet

Tetrabenazine (12.5mg)

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Atrest 12.5 Tablet is used to treat chorea (which is a movement disorder characterized by involuntary, jerky movements) associated with Huntington's disease. It balances dopamine levels, reducing movements and improving function. This helps it easier for the person to move and function better.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Shilpa Garcha, MD (Pharmacology), MBBS,
Last updated on 12 Nov 2024 | 01:09 AM (IST)

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10 tablets

Gurgaon

Cash on delivery

Available

Free Return

within 7 days

Expiry after

Sep, 2026

General Information

Contains

Tetrabenazine (12.5mg)

Marketer

Centaur Pharmaceuticals Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Atrest 12.5 Tablet should be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. This medication must not be stopped suddenly without talking to your doctor as it may worsen your symptoms. However, discontinue this medicine immediately if you experience neuroleptic malignant syndrome, characterized by fever, muscle rigidity, and altered consciousness or seizures.

Some common side effects of this medicine include nausea, insomnia(difficulty sleeping), anxiety, fatigue, akathisia (restlessness and inability to stay still), and depression. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts while taking this medicine.

Uses of Atrest Tablet

Treatment of chorea (a movement disorder) associated with Huntington's disease

Benefits of Atrest Tablet

Treatment of chorea (a movement disorder) associated with Huntington's disease
Chorea is a movement disorder characterized by involuntary, jerky movements that can be associated with Huntington's disease. Atrest 12.5 Tablet helps to treat these symptoms and also controls these jerky movements. This medicine can therefore enhance the quality of life by improving the ability to carry out daily functions in a better manner.

Side effects of Atrest Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Atrest

Nausea
Insomnia (difficulty in sleeping)
Anxiety
Fatigue
Sleepiness
Akathisia (inability to stay still)
Depression

How to use Atrest Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Atrest 12.5 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Atrest Tablet works

Atrest 12.5 Tablet works by depleting the stores of certain chemical messengers (such as dopamine, serotonin, norepinephrine, and histamine) in the brain that helps in controlling body movements.

Quick tips

You have been prescribed Atrest 12.5 Tablet to help control movement disorders such as in Huntington’s disease.
Be cautious while driving or doing anything that requires concentration as Atrest 12.5 Tablet can cause dizziness and sleepiness.
Inform your doctor if you experience symptoms such as high fever, sweating, muscle stiffness, and faster breathing. These may be due to a rare side effect known as the neuroleptic malignant syndrome.
Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Do not stop taking Atrest 12.5 Tablet without talking to your doctor first as it may cause worsening of symptoms.

Safety advice

Alcohol

UNSAFE

Atrest 12.5 Tablet may cause excessive drowsiness with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

Atrest 12.5 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Atrest 12.5 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Atrest 12.5 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Atrest 12.5 Tablet in patients with kidney disease. Please consult your doctor.
However, caution is advised in these patients.

Liver

UNSAFE

Atrest 12.5 Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

Frequently asked questions

Can Atrest 12.5 Tablet be crushed?

No, Atrest 12.5 Tablet should not be crushed, cut, or chewed. It needs to be swallowed as a whole. But if you cannot swallow the whole tablet, tell your doctor who will probably prescribe you another medicine.

Is Atrest 12.5 Tablet an antipsychotic?

Atrest 12.5 Tablet is not an antipsychotic. It belongs to the vesicular monoamine transporter 2 (VMAT2) inhibitor class of medicines. It works by changing the activity of some natural substances in the brain that affect muscles and nerves.

What is the most important information that I should know about Atrest 12.5 Tablet?

Atrest 12.5 Tablet may increase the risk of depression or suicidal thoughts in patients with Huntington’s disease. Huntington’s disease is an inherited disease that causes the progressive breakdown of nerve cells in the brain. Therefore, you should not take Atrest 12.5 Tablet if you have Huntington’s disease along with depression.

What should I avoid while taking Atrest 12.5 Tablet?

Sleepiness is a common side effect of Atrest 12.5 Tablet. Therefore, you should avoid driving or operating heavy machinery if you feel sleepy while taking Atrest 12.5 Tablet.

Can I stop taking Atrest 12.5 Tablet on my own?

No, you should not stop taking Atrest 12.5 Tablet suddenly, without talking to your doctor. Sudden discontinuation of the medicine may cause neuroleptic malignant syndrome. This can be characterized by high fever, stiff muscles, confusion, hallucinations, increased sweating, and very fast or uneven heart beat. Hence, to avoid such side effects your doctor will gradually reduce your dose.

Can I take alcohol while on Atrest 12.5 Tablet?

You should avoid alcohol since it may add to the sleepiness caused by Atrest 12.5 Tablet. Similarly, you should avoid taking medicines which cause sleepiness. If you are not sure about the effects of the medicine, consult with your doctor.

Does Atrest 12.5 Tablet affect blood pressure?

Yes, Atrest 12.5 Tablet may affect the blood pressure. In some patients it may decrease the levels of blood pressure. Along with that, one may experience dizziness, lightheadedness, and fainting while getting up quickly from a lying position (orthostatic hypotension). To avoid this problem, get out of bed slowly, rest your feet on the floor for a few minutes before standing up.

Fact Box

Chemical Class

Tetrahydroisoquinoline Derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Monoamine depletor- Tetrabenazine

References

Aminoff MJ. Pharmacologic Management of Parkinsonism & Other Movement Disorders. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 480.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1337-38.
Tetrabenazine. Washington, DC: Prestwick Pharmaceutical; 2008. [Accessed 19 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
Tetrabenazine [Product Label]. Centuar Pharma. [Accessed 07 Aug. 2023]. (online) Available from:

User feedback

Patients taking Atrest 12.5 Tablet

Twice A Day

51%

Once A Day

34%

Thrice A Day

15%

What are you using Atrest Tablet for?

Huntington's disease

100%

How much was the improvement?

Poor

67%

Average

33%

What were the side-effects while using Atrest 12.5 Tablet?

No Side Effect

100%

How do you take Atrest Tablet?

With food

100%

Please rate Atrest 12.5 Tablet on price

Expensive

67%

Average

33%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Centaur Pharmaceuticals Pvt Ltd
Address: CENTAUR HOUSE, Near Grand Hyatt, Vakola ,Santacruz – East, Mumbai – 400 055, India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Atrest 12.5 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Why we need a prescription?

Atrest 12.5 Tablet

Cash on delivery

Free Return

Expiry after

General Information

Contains

Marketer

Storage

Product introduction

Uses of Atrest Tablet

Benefits of Atrest Tablet

Side effects of Atrest Tablet

How to use Atrest Tablet

How Atrest Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

Can Atrest 12.5 Tablet be crushed?

Is Atrest 12.5 Tablet an antipsychotic?

What is the most important information that I should know about Atrest 12.5 Tablet?

What should I avoid while taking Atrest 12.5 Tablet?

Can I stop taking Atrest 12.5 Tablet on my own?

Can I take alcohol while on Atrest 12.5 Tablet?

Does Atrest 12.5 Tablet affect blood pressure?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Atrest 12.5 Tablet

What are you using Atrest Tablet for?

How much was the improvement?

What were the side-effects while using Atrest 12.5 Tablet?

How do you take Atrest Tablet?

Please rate Atrest 12.5 Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

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