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Avastin 100mg Injection

Written By Dr. Lipika Khurana, PGDHHM, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 12 Nov 2024 | 01:00 AM (IST)
Avastin 100mg Injection is an anticancer medication. It is used in the treatment of cancer of colon and rectum, non-small cell lung cancer, kidney cancer, brain tumor, ovarian and cervical cancer. It helps to prevent the growth of new blood vessels that feed tumors and stops tumors from growing.
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General Information

Contains

Bevacizumab (100mg)

Marketer

Roche Products India Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Avastin 100mg Injection image
Avastin 100mg Injection image

Product introduction

Avastin 100mg Injection is an effective medicine, first-line option when used together with other cancer medicines. It is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. The doctor will decide your dose and duration and will check you for signs of an infusion reaction such as high blood pressure and trouble breathing. You keep taking Avastin 100mg Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking it or not. You may be advised to check blood pressure and levels of protein in urine while you are taking this medication.




The most common side effects of this medicine include rectal bleeding, taste change, and headache. Inform your doctor that you are taking this medication before undergoing any surgical procedure, as the drug has ability to lower the ability of wound healing. Other than this, it also enhances your risk of bleeding thus if you notice any unusual bleeding or bleeding consult with your doctor immediately.




Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.




There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details.

Side effects of Avastin Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Avastin
  • Nosebleeds
  • Headache
  • High blood pressure
  • Inflammation of the nose
  • Protein in urine
  • Taste change
  • Dry skin
  • Hemorrhage
  • Increased lacrimation
  • Back pain
  • Exfoliative dermatitis

How to use Avastin Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Avastin Injection works

Avastin 100mg Injection is a anti-angiogenic medication. It works by blocking a protein called vascular endothelial growth factor (VEGF). This stops the formation of blood vessels that bring oxygen and nutrients to cancerous cells.

Quick tips

  • Avastin 100mg Injection is an effective, first-line option when used together with other medicines for certain types of cancers such as colorectal, lung, cervical, and kidney cancers.
  • Avastin 100mg Injection is given as an infusion. Your doctor or nurse will monitor you for signs of an infusion reaction such as high blood pressure and trouble breathing.
  • It can lower your wound healing ability. Inform your doctor that you are taking this medication before undergoing any surgical procedure.
  • It can increase the risk of bleeding. Inform your doctor if you notice any unusual bleeding or bleeding that doesn't stop easily.
  • Your doctor may regularly check your blood pressure and levels of protein in your urine while you are on Avastin 100mg Injection.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Avastin 100mg Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Avastin 100mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Avastin 100mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving

Driving

UNSAFE
Avastin 100mg Injection may cause side effects which could affect your ability to drive.
Sleepiness and fainting have been reported with Avastin 100mg Injection and this may impair your ability to drive.
Kidney

Kidney

SAFE IF PRESCRIBED
Avastin 100mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Avastin 100mg Injection may not be needed in these patients. Please consult your doctor.
Liver

Liver

SAFE IF PRESCRIBED
Avastin 100mg Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Avastin 100mg Injection may not be needed in these patients. Please consult your doctor.

Frequently asked questions

Avastin 100mg Injection is approved for the treatment of cancer of the colon or rectum that has spread to other parts of the body. It must be given along with chemotherapy. Other types of cancers that it helps with includes certain types of lung cancer, kidney cancer, ovarian cancer, cervical cancer, and glioblastoma (a type of brain tumor).
Avastin 100mg Injection is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. Your doctor will decide your dose and duration and will monitor you for signs of an infusion reaction.
You keep taking Avastin 100mg Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking Avastin 100mg Injection. If your cancer progresses during this initial treatment, talk to your doctor if a different chemotherapy may be an option.
Chemotherapy attacks fast-growing cells, like cancer cells. In contrast, the purpose of Avastin 100mg Injection is to prevent the growth of new blood vessels that feed tumors. This causes the tumour to shrink, or to stop growing.
Chemotherapy is still needed along with taking Avastin 100mg Injection. It makes chemotherapy work better.

Fact Box

Chemical Class

Monoclonal antibody (mAb)

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Vascular endothelial growth factor (VEGF) inhibitor

References

  1. Avastin (Bevacizumab) [Product Information]. [Accessed 07 Oct. 2024] (online) Available from:
  2. Avastin (Bevacizumab) [Prescribing Information]. South San Francisco, CA: Genentech, Inc.; 2022. [Accessed 07 Oct. 2024] (online) Available from:
  3. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1739-40.
  4. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955.
  5. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 142-43.
  6. Bevacizumab. South San Francisco, California: Genentech, Inc.; 2004 [revised Sep. 2011]. [Accessed 26 Mar. 2019] (online) Available from:
  7. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Bevacizumab. [Updated 2019 Jul 20]. [Accessed 18 Feb. 2020] (online) Available from:
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User feedback

Cancer of colon and rectum
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Average
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Altered taste
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Roche Products India Pvt Ltd
Address: 1503, 15th Floor, ‘The Capital’, Plot no. C-70, Behind ICICI Bank, BKC, Bandra (E) , Mumbai 400051

Vendor Details

Country of origin: India
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