Bivaflo 250mg Injection

Written By Dr. Balshine Singh Kanwar, MD, MBBS

Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology

Last updated on 07 Nov 2024 | 01:08 AM (IST)

Bivaflo 250mg Injection belongs to a group of medicines known as an anticoagulant or blood thinner. It helps prevent and treat blood clots. It is used to reduce the risk of stroke and heart attack. It also prevents and treats clot formation in the veins of your legs, lungs, brain, and heart.

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General Information

Contains

Bivalirudin (250mg)

Marketer

Sun Pharmaceutical Industries Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Bivaflo 250mg Injection is commonly used in patients with irregular heart rhythm (atrial fibrillation) to prevent clot formation. It also reduces the risk of getting clots in people who have undergone knee or hip replacement surgeries. It is given as a drip into a vein by a doctor or a nurse. You can reduce your risk of having a blood clot by making changes to your lifestyle, such as not smoking, eating a healthy diet, exercising regularly, and losing weight if you need to.

The most common side effects of this medicine are headache, low platelet level, and fever. It may also make you bleed more easily than normal, for example, having nosebleeds or bruising. You should be extra careful while shaving, cutting nails, or using sharp objects during treatment with this medicine.

This medicine may not be suitable for everyone and should be used with caution. Inform your doctor, if you have severe kidney or liver problems. Do not take this medicine if you are currently bleeding or if you are taking other medicines to reduce blood clotting. You should not breastfeed while using this medicine. Unlike other anticoagulants, a regular blood test (PT-INR) is not required while taking this medicine.

Uses of Bivaflo Injection

Treatment and prevention of Blood clots

Benefits of Bivaflo Injection

Treatment and prevention of Blood clots
Bivaflo 250mg Injection is a type of medicine known as an anticoagulant. Although it does not “dissolve” blood clots, it can prevent them from getting bigger so your body can dissolve them over time. It will also prevent new ones from forming. It works by blocking a substance in the body which is involved in blood clotting. This keeps your blood flowing freely around your body and makes it less likely that a clot will form inside a blood vessel.

This can help prevent or reduce damage caused by stroke, clots in your lungs (pulmonary embolism) or other blood vessels (thrombosis). It can also make it less likely that parts of a clot will break off and travel to other parts of the body. It is given as an infusion (drip) into a vein under the supervision of a doctor. You should make appropriate lifestyle changes to help this medicine be effective.

Side effects of Bivaflo Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Bivaflo

Low blood platelets
Headache
Fever
Bleeding

How to use Bivaflo Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Bivaflo Injection works

Bivaflo 250mg Injection is an anticoagulant that prevents the formation of harmful blood clots.

All substitutes for Bivaflo 250mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

It is a hospital only medicine. It is given by your nurse or doctor as an infusion (drip) into a vein.
Notify your doctor if you see blood in your vomit, urine or stool (black, tarry stools or bright red blood).
Inform your doctor if you are taking other blood thinners or medicines to prevent blood clots.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Bivaflo 250mg Injection.

Pregnancy

SAFE IF PRESCRIBED

Bivaflo 250mg Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

CONSULT YOUR DOCTOR

Bivaflo 250mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

NOT RELEVANT

Not relevant, as Bivaflo 250mg Injection is intended for use in hospitalised patients.

Kidney

CAUTION

Bivaflo 250mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Bivaflo 250mg Injection may be needed. Please consult your doctor.
Use of Bivaflo 250mg Injection is not recommended in patients with severe kidney disease and patients undergoing dialysis.

Liver

SAFE IF PRESCRIBED

Bivaflo 250mg Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Bivaflo 250mg Injection may not be needed in these patients. Please consult your doctor.

Frequently asked questions

Does Bivaflo 250mg Injection affect the liver?

Unlike other anticoagulants, Bivaflo 250mg Injection usually does not affect the functioning of the liver. But long-term use of Bivaflo 250mg Injection may increase the chances of mild liver injury in patients with elevated liver enzymes. However, the overall chances of developing any such problem are lower than other anticoagulants. It is advised that you inform your doctor if you have a history of liver disease before starting this medicine.

Can I drink alcohol with Bivaflo 250mg Injection?

Taking alcohol while taking Bivaflo 250mg Injection can increase the blood-thinning effect of this medicine, thereby increasing the chance of bleeding. Regular intake of alcohol can lead to a gastric ulcer which might again cause bleeding. So, it is better to avoid alcohol while you are taking this medicine. Do consult your doctor if any such episode of bleeding occurs.

How should I store Bivaflo 250mg Injection?

Bivaflo 250mg Injection should be stored at room temperature between 20º-25º C (68º-77°F) in the original carton it came in. Do not freeze. Store the medicine at a dry place and protect the medicine from moisture and light.

When will I feel better after taking Bivaflo 250mg Injection?

Bivaflo 250mg Injection reduces your risk of developing blood clots in the blood vessels of your leg, lungs, heart and brain. You may not feel any difference after taking Bivaflo 250mg Injection. However, keep taking this medicine as prescribed by your doctor because you will still be getting its full benefits.

Who should not take Bivaflo 250mg Injection?

People experiencing any unusual bleeding or people allergic to Bivaflo 250mg Injection should not take it. Bivaflo 250mg Injection should also be avoided by people with artificial (prosthetic) heart valves. Therefore, inform your doctor if you have ever had or plan to have a valve in your heart replaced. Also, the use of this medicine is not recommended in patients with severe kidney disease.

Can the use of Bivaflo 250mg Injection increase the risk of bleeding?

Yes, Bivaflo 250mg Injection may increase the risk of bleeding. Always be careful while doing activities that may cause an injury or bleeding. Tell your doctor immediately if you notice any abnormal bruising or bleeding.

Can Bivaflo 250mg Injection cause hair loss?

No, Bivaflo 250mg Injection does not usually cause hair loss. However, there do exist some rare reports of hair loss associated with Bivaflo 250mg Injection. Consult your doctor if you face hair loss while taking Bivaflo 250mg Injection to rule out any other causes of hair loss.

Fact Box

Chemical Class

Polypeptides

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Direct thrombin inhibitor- parenteral

References

Weitz JI. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 859-60.
Zehnder JL. Drugs Used in Disorders of Coagulation. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 594.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 147-48.
Fox KA, White HD, Gersh BJ, et al. Antithrombotic Agents: Platelete Inhibitors, Acute Anticoagulants, Fibrinolytics, and Chronic Anticoagulants. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. pp. 371-73.
Bivalirudin. Parsippany, New Jersey: The Medicines Company; 2000 [revised Mar. 2016]. [Accessed 15 Mar. 2019] (online) Availabble from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Bivalirudin. [Updated 2018 Dec 3]. [Accessed 19 Feb. 2020] (online) Available from:

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Patient concerns

My father in law is being admitted in hospital due to blood clot in brain. His right leg and arm seems to be paralysed. Doctors in the hospital not briefing us on the problem exactly. Need your second opinion. His age is 67. Having Smoking habit.

Dr. Sunil Sekhri

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There are blood clots in the brain arteries

In 3 months pregnancy some blood clots have came

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sun Pharmaceutical Industries Ltd
Address: Plot no 107/108,Namli block , Ranipool, East Sikkim 737135

Vendor Details

Country of origin: India

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