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Bosentan 125 Tablet

Written By Dr. Anuj Saini, MMST, MBBS
Reviewed By Dr. Ashish Ranjan, MD (Pharmacology), MBBS
Last updated on 11 Nov 2024 | 01:11 AM (IST)
Bosentan 125 Tablet is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It even helps to improve your quality of life, exercising ability and delay in disease progression.
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General Information

Contains

Bosentan (125mg)

Marketer

Care Formulation Labs Pvt Ltd

Storage

Store below 30°C
The content is shown in English
Bosentan 125 Tablet image

Product introduction

Bosentan 125 Tablet should be taken with or without food. This medicine should be used regularly to get the most benefit from it. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you.

The most common side effects of this medicine include headache, swelling of the legs and ankles, and diarrhea.  If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some serious side effects which mean your doctor should know immediately include Anemia (low number of red blood cells) and abnormal liver function such as nausea, vomiting, dark urine, fever, and dark urine. Your doctor might check you for blood tests to check for anemia and liver function.

Before taking this medicine, let your doctor know if you have liver dysfunctioning. Inform your doctor if you are pregnant or breastfeeding. Women are suggested to use reliable contraceptive pills to avoid pregnancy and should continue even after one month of stopping the treatment. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.

Uses of Bosentan Tablet

Benefits of Bosentan Tablet

Pulmonary arterial hypertension (PAH)
Pulmonary arterial hypertension can cause shortness of breath, tiredness, dizziness, chest pain and swelling in your ankles and legs. It is caused by thickening of walls of the arteries that supply your lungs making it hard for blood to get through. Bosentan 125 Tablet relaxes the blood vessels and can help lower the blood pressure in the arteries of your lungs. You will be able to carry out your daily activities more easily and feel less tired or dizzy.

Side effects of Bosentan Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Bosentan
  • Headache
  • Ankle swelling
  • Edema (swelling)
  • Diarrhea
  • Anemia (low number of red blood cells)
  • Respiratory tract infection

How to use Bosentan Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Bosentan 125 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Bosentan Tablet works

Bosentan 125 Tablet is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Bosentan 125 Tablet helps relax these blood vessels and increases the supply of blood to the lungs.

All substitutes for Bosentan 125 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Bosentas 125 Tablet

by Cipla Ltd
₹131.9/tablet
17% cheaper
<h3 class=bodySemiBold>Bosentas 125 Tablet</h3>

Bosenat 125 Tablet

by Natco Pharma Ltd
₹121.9/tablet
23% cheaper
<h3 class=bodySemiBold>Bosenat 125 Tablet</h3>

Bozetan 125mg Tablet

by Lupin Ltd
₹184.3/tablet
16% costlier
<h3 class=bodySemiBold>Bozetan 125mg Tablet</h3>

Quick tips

  • Your doctor has prescribed Bosentan 125 Tablet to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
  • It helps improve your quality of life, exercising ability, and delay disease progression.
  • Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
  • Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
  • Do not drive or do anything requiring concentration until you know how Bosentan 125 Tablet affects you.
  • Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Bosentan 125 Tablet as it is toxic to an unborn baby.
  • Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
  • Inform your doctor if you notice yellowing of skin/eye, dark urine, or stomach pain.

Safety advice

Alcohol

Alcohol

UNSAFE
Bosentan 125 Tablet may cause excessive drowsiness with alcohol.
Pregnancy

Pregnancy

UNSAFE
Bosentan 125 Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Bosentan 125 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving

Driving

UNSAFE
Bosentan 125 Tablet may cause side effects which could affect your ability to drive.
As Bosentan 125 Tablet can induce hypotension (decrease of your blood pressure) which can make you feel dizzy and this can affect your ability to drive.
Kidney

Kidney

SAFE IF PRESCRIBED
Bosentan 125 Tablet is safe to use in patients with kidney disease. No dose adjustment of Bosentan 125 Tablet is recommended.
Liver

Liver

CAUTION
Bosentan 125 Tablet should be used with caution in patients with liver disease. Dose adjustment of Bosentan 125 Tablet may be needed. Please consult your doctor.
Use of Bosentan 125 Tablet is not recommended in patients with moderate and severe liver disease.

Frequently asked questions

Bosentan 125 Tablet is given as a tablet form and can be taken with or without food. The tablets are to be taken twice daily in the morning and evening. The exact dosage and frequency of dose will be decided by the doctor on the basis of age and weight of the patient.
Yes, there are chances that Bosentan 125 Tablet may cause anemia. It can cause a dose-related decrease in hemoglobin in the blood which could lead to anemia. Regular hemoglobin check is advised while taking this medicine and consult your prescribing doctor for his advice. In some cases, blood transfusion is done to treat anemia.
It has been found that in some cases Bosentan 125 Tablet can cause liver damage in patients who are prone to have liver disease. This medicine can also lead to increased liver enzymes. Hence, it should be used with caution in prone patients or in patients with history of liver disease. Before starting the medication inform your doctor if you have had a history of liver disease.
No, Bosentan 125 Tablet is not safe during pregnancy. There is evidence to show that it can cause major birth defects in the newborn baby and can harm the baby in womb. It is not advised to take Bosentan 125 Tablet if you are planning to become pregnant. You should use reliable contraception methods while you take Bosentan 125 Tablet. Consult your doctor before starting this medication or planning pregnancy.

Fact Box

Chemical Class

Sulfonamide and Pyrimidine Derivative

Habit Forming

No

Therapeutic Class

CARDIAC

Action Class

Endothelin receptor blocker

References

  1. Barnes PJ. Pulmonary Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1059.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 154-56.
  3. Bosentan. Beerse Belgium: Janssen-Cilag International NV; 2013 [revised Sep. 2018]. [Accessed 01 Apr. 2019] (online) Available from:
  4. Bosentan. South San Francisco, California: Actelion Pharmaceuticals US, Inc.; 2001 [revised Aug. 2009]. [Accessed 23 Jan. 2019] (online) Available from:
  5. Bosentan. South San Francisco, CA: Actelion Pharmaceuticals; 2001. [Accessed 01 Apr. 2019] (online) available from:
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:
  7. Bosentan [Prescribing Information]. Titusville, NJ: Actelion Pharmaceuticals US, Inc.; 2022. [Accessed 09 Jun, 2023] (online) Available from:
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Patient concerns

Having high Pulmonary Atrial Hypertension

Dr. Nabajit Talukdar
Dr. Nabajit Talukdar
Interventional Cardiology
What medicines r u on

Hiii my wife having hurt patient ( pulmonary hypertension ) she's taking pulmonext 5mg tablet but this tablet is very costly for me of Rs. 1450/- 10tab. I want to know any another tablet available in same drugs with low price

Dr. Sfurti Mann
Dr. Sfurti Mann
Diabetology
This can't be decided online Your doctor is the best judge about your patients pulmonary hypertension
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Care Formulation Labs Pvt Ltd
Address: D-1659, DSIIDC, Narela Industrial Area, Delhi, 110040

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Bosentan 125 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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