Cadinib 400mg Tablet

Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology

Last updated on 08 Nov 2024 | 01:05 AM (IST)

Cadinib 400mg Tablet is used to treat several types of cancers. It is most commonly prescribed to treat blood cancers (chronic myeloid leukemia and acute lymphocytic leukemia) and gastrointestinal stromal tumors. It works by targeting specific proteins that contribute to the growth and spread of cancer cells.

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10 tablets

General Information

Contains

Imatinib mesylate (400mg)

Marketer

Cadila Pharmaceuticals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Cadinib 400mg Tablet is also used for treatment of a skin tumor called dermatofibrosarcoma protuberans and a type of bone marrow condition called aggressive systemic mastocytosis. The medicine should be taken with food. Take it at the same time each day to get the most benefit. Continue taking it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue, and abdominal pain. Let your doctor know if you experience unexpected rapid weight gain. Your doctor may advise for regular monitoring of blood cells and liver function while you are taking this medicine. Do not drive or do anything requiring mental focus if you experience dizziness and blurry vision.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Cadinib Tablet

Treatment of Cancer

Benefits of Cadinib Tablet

Treatment of Cancer
In several types of cancers like blood cancers, gastrointestinal stromal tumors, skin cancer (dermatofibrosarcoma protuberans), and bone marrow condition (aggressive systemic mastocytosis), Cadinib 400mg Tablet targets the specific proteins that contribute to the growth and spread of cancer cells. By stopping these proteins, the medicine slows down or even stops the growth of cancer. This helps shrink tumors, slow down their growth, and make the patients feel better.

Side effects of Cadinib Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Cadinib

Edema (swelling)
Nausea
Vomiting
Muscle cramp
Musculoskeletal (bone, muscle or joint) pain
Diarrhea
Rash
Fatigue
Abdominal pain
Bleeding
Breathing problems
Cough
Weight gain
Dry eye
Dizziness
Hemorrhage

How to use Cadinib Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cadinib 400mg Tablet is to be taken with food.

How Cadinib Tablet works

Cadinib 400mg Tablet is an anti-cancer medication. A protein enzyme, bcr-abl tyrosine kinase, responsible for the growth of abnormal proliferation of cancer cells. This medicine inhibits the proliferation and induces apoptosis (planned cell death) in bcr-abl positive cells (cancer cells). This is how it works to stop or slow the spread of cancer.

All substitutes for Cadinib 400mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Always take it with food and a full glass of water to prevent nausea.
It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
Water retention and swelling are very common side effects of Cadinib 400mg Tablet. Notify your doctor if you have unexpected rapid weight gain.
Do not change the dose or discontinue use without consulting your doctor.
Notify your doctor about all the medications you are taking, including over the counter medicines and dietary supplements.
Your doctor may get regular blood tests done to monitor your liver function and the number of blood cells in your blood.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Cadinib 400mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Cadinib 400mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Cadinib 400mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Lactating women should not breastfeed while using this drug and 15 days after stopping it.

Driving

UNSAFE

Cadinib 400mg Tablet may cause side effects which could affect your ability to drive.

Kidney

CAUTION

Cadinib 400mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Cadinib 400mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Cadinib 400mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Cadinib 400mg Tablet may be needed. Please consult your doctor.

Frequently asked questions

Can Cadinib 400mg Tablet be taken with food?

Yes, the best way to take it is with a glass of water and food. This prevents irritation in the food pipe and stomach. If you cannot swallow it, put the tablets in a glass of water or apple juice (approximately 50 ml for a 100 mg tablet and 200 ml for a 400 mg tablet). Stir it with a spoon to make it uniform and drink it immediately.

Is it safe to drive while taking Cadinib 400mg Tablet?

Cadinib 400mg Tablet may cause dizziness, lightheadedness or drowsiness in some people. Make sure you know how you react to it before you drive a car or operate machinery.

What precautions need to be followed while taking Cadinib 400mg Tablet?

While taking Cadinib 400mg Tablet, make sure you follow all the instructions given by your doctor, carefully and keep all appointments. You will need regular follow-up to ensure that the treatment is working. Regular blood tests, weight checks, and urine tests may be required to find out any side effects before it becomes serious. Make sure you use a method of contraception to prevent pregnancy during treatment with Cadinib 400mg Tablet. Tell your doctor immediately if you become pregnant while you are taking this medicine. If you are about to start taking any new medicine, remind your doctor that you are taking Cadinib 400mg Tablet.

Ever since I started using Cadinib 400mg Tablet, I have noticed that I develop rashes and severe itching when I have sun exposure. Is it because of the medicine or the disease?

This medicine may make your skin much more sensitive to sunlight than it normally is. Exposure to sunlight may cause skin rash, itching, redness or severe sunburn. When you are outdoors, wear protective clothing and use a sunscreen with an SPF of 15 or higher. If you feel a burning sensation on your skin, tell your doctor.

The doctor has advised me not to take any medicine on my own while taking Cadinib 400mg Tablet. Should I consult my doctor even if I need to take paracetamol for my fever?

Yes, there are a number of medicines which interfere with Cadinib 400mg Tablet, including paracetamol. Therefore you should not self medicate while taking Cadinib 400mg Tablet. Other medicines which interfere with Cadinib 400mg Tablet include cyclosporin, dexamethasone (a steroid), warfarin, antiviral medicines which treat AIDS and some medicines which treat bacterial infections, high cholesterol, high blood pressure, heart problems, and mental disorders and depression. Consult your doctor before taking any medicine, and inform him that you are on Cadinib 400mg Tablet therapy.

Can I expect that if I take Cadinib 400mg Tablet regularly and as advised by the doctor for CML, I will be cured?

Cadinib 400mg Tablet has proved effective in many cases of CML. It is also noticed that the chances of survival increase after taking this medicine. The doctor who is treating CML can tell you better. The doctor will analyze your current state, blood test results, response to treatment, any other medical illness which you may be having, etc. and tell you.

Fact Box

Chemical Class

Benzanilides Derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine kinase inhibitors

References

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1732-34.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 953.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 692-94.
Imatinib mesylate. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2001 [revised Jan 2012]. [Accessed 23 Jan. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Imatinib. [Updated 2018 Oct 31]. [Accessed 18 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:
Natco Pharma Limited. Safety Data Sheet: Imatinib Mesylate. 2019. [Accessed 05 Jul. 2023]. (online) Available from:
CiplaMed. Imatinib mesylate [Prescribing Information]. [Last Revised: 26 Apr. 2021]. [Accessed 05 Jul. 2023]. (online) Available from:

User feedback

What are you using Cadinib Tablet for?

Blood cancer (Chronic myeloid leukaemia)

100%

Patient concerns

Sir my brother have skin cancer can you do something for save his life ??

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

Treatment of cancer depends on whether it is localized or metastatic cancer

How we can find out parient is CA and which report we can do for know the patient is CA

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

Thr is no single test for cancerWhich cancer ur looking for

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Cadila Pharmaceuticals Ltd
Address: Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, INDIA.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Cadinib 400mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Cadinib 400mg Tablet

General Information

Contains

Marketer

Storage

Product introduction

Uses of Cadinib Tablet

Benefits of Cadinib Tablet

Side effects of Cadinib Tablet

How to use Cadinib Tablet

How Cadinib Tablet works

All substitutes for Cadinib 400mg Tablet

Imat 400 Tablet

Imatib 400 Tablet

Levin 400mg Tablet

Glivec 400mg Tablet

Imatinib 400 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

Can Cadinib 400mg Tablet be taken with food?

Is it safe to drive while taking Cadinib 400mg Tablet?

What precautions need to be followed while taking Cadinib 400mg Tablet?

Ever since I started using Cadinib 400mg Tablet, I have noticed that I develop rashes and severe itching when I have sun exposure. Is it because of the medicine or the disease?

The doctor has advised me not to take any medicine on my own while taking Cadinib 400mg Tablet. Should I consult my doctor even if I need to take paracetamol for my fever?

Can I expect that if I take Cadinib 400mg Tablet regularly and as advised by the doctor for CML, I will be cured?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

What are you using Cadinib Tablet for?

Patient concerns

Sir my brother have skin cancer can you do something for save his life ??

How we can find out parient is CA and which report we can do for know the patient is CA

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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