Heptral 400mg Tablet
Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Varun Gupta, MD Pharmacology, MBBS
Last updated on 12 Nov 2024 | 01:12 AM (IST)
Heptral 400mg Tablet is a medicine used for the treatment of liver disease associated with reduced bile formation (intrahepatic cholestasis). It protects the liver cells from toxins and helps the liver to perform its normal functions.
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General Information
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Product introduction
Heptral 400mg Tablet may be taken with or without food. The dose will depend on what you are being treated for and your body weight. This medicine needs to be taken regularly to get the most benefit and you may have to take it for several months or longer, so try to get into a routine. Keep using it as prescribed even if your symptoms disappear.
The most common side effects are nausea, diarrhea, upset stomach, constipation, and dizziness. Not everyone gets side effects. If you are worried about them, or they do not go away, let your doctor know. If you have problems with diarrhea your doctor may reduce the dose or stop the treatment. Drink enough of water or fluids to stay hydrated in case of severe diarrhea and constipation.
Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. Using this medicine can reduce or increase the effect of some other medicines so tell your doctor, all other medicines you are taking. Avoid drinking alcohol as it might increase side effects.
The most common side effects are nausea, diarrhea, upset stomach, constipation, and dizziness. Not everyone gets side effects. If you are worried about them, or they do not go away, let your doctor know. If you have problems with diarrhea your doctor may reduce the dose or stop the treatment. Drink enough of water or fluids to stay hydrated in case of severe diarrhea and constipation.
Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. Using this medicine can reduce or increase the effect of some other medicines so tell your doctor, all other medicines you are taking. Avoid drinking alcohol as it might increase side effects.
Uses of Heptral Tablet
- Treatment of Liver disease
Benefits of Heptral Tablet
Treatment of Liver disease
Intrahepatic cholestasis is a type of liver disease that is associated with low bile formation. Heptral 400mg Tablet is used to treat this condition and may be used alone or with other medicines. It protects the liver cells from toxins and helps the liver to perform its normal functions. Once you start this treatment, it is likely that you will be taking it for a long time. To make the medicine more effective and for general health benefits, stop smoking, maintain a healthy weight, and do not drink too much alcohol.
Intrahepatic cholestasis is a type of liver disease that is associated with low bile formation. Heptral 400mg Tablet is used to treat this condition and may be used alone or with other medicines. It protects the liver cells from toxins and helps the liver to perform its normal functions. Once you start this treatment, it is likely that you will be taking it for a long time. To make the medicine more effective and for general health benefits, stop smoking, maintain a healthy weight, and do not drink too much alcohol.
Side effects of Heptral Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Heptral
- Nausea
- Diarrhea
- Upset stomach
- Constipation
- Dizziness
How to use Heptral Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Heptral 400mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Heptral Tablet works
Heptral 400mg Tablet protects the liver cells from toxins and helps the liver to perform its normal functions.
All substitutes for Heptral 400mg Tablet
For information purposes only. Consult a doctor before taking any medicine.
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Quick tips
- It protects the liver cells from toxins and helps the liver to perform its normal functions.
- Take it as per dose and duration suggested by your doctor.
- Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
- Consult with your doctor if you are pregnant, planning pregnancy or breastfeeding.
Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Heptral 400mg Tablet. Please consult your doctor.

Pregnancy
CONSULT YOUR DOCTOR
Information regarding the use of Heptral 400mg Tablet during pregnancy is not available. Please consult your doctor.

Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Heptral 400mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving
CONSULT YOUR DOCTOR
It is not known whether Heptral 400mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Heptral 400mg Tablet in patients with kidney disease. Please consult your doctor.

Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Heptral 400mg Tablet in patients with liver disease. Please consult your doctor.

Frequently asked questions
Heptral 400mg Tablet is a natural substance found in cells, tissue, and body fluids. It is produced from methionine, an amino acid containing sulfur, and adenosine triphosphate (ATP). The nutritional supplement is harvested from yeast (fungus) cell cultures.
Heptral 400mg Tablet has been studied extensively for depression, osteoarthritis, and depression. But, there is no conclusive evidence that it is helpful in these conditions.
Patients with bipolar disorder (an illness characterized by mood swings, from depression to mania) should not be given Heptral 400mg Tablet for depression as it can worsen symptoms of mania. Also, consult your doctor if you are pregnant or nursing mother, have Parkinson’s disease or if you are HIV-positive.
The side effects of Heptral 400mg Tablet are usually not very serious. These side effects include headache, nausea, and diarrhea. However, these effects are not very common.
Information on long term safety of Heptral 400mg Tablet is limited. There is one study in which patients took it for 2 years and no serious side effects were reported.
Fact Box
Chemical Class
5'-deoxy-5'-thionucleosides Derivative
Habit Forming
No
Therapeutic Class
GASTRO INTESTINAL
Action Class
Hepatoprotectives
References
- Medscape. Ademetionine. [Accessed 28 Mar. 2019] (online) Available from:
- Drugs.com. Ademetionine. [Accessed 28 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Dec. 2019] (online) Available from:
- Ademetionine [Product Label]. Ahmedabad, Gujarat: La Renon Healthcare Private Limited; 2022. [Accessed 09 Jun, 2023] (online) Available from:
- Mount Sinai. S-adenosylmethionine. [Accessed 09 Jun, 2023] (online) Available from:

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User feedback
Twice A Day
72%
Once A Day
15%
Thrice A Day
13%
Four Times A Day
1%
Others
62%
Nutritional deficiencies
38%
Excellent
39%
Average
36%
Poor
25%
No Side Effect
27%
Insomnia (difficulty in sleeping)
18%
Dizziness
18%
Acute toxicity
9%
Constipation
9%
Empty stomach
67%
With food
33%
Expensive
51%
Average
28%
Not Expensive
21%
Patient concerns
In LFT SGPT is 83 and SGOT is 50 and bilirubin is 1 and I have fatty liver and triglycerides is 161 Medicines prescribed are 1. Silybon 145 mg 2. Urosol 3. Heptral 400 mg Please describe my problem and medicines are okay?
Dr. Sfurti Mann
Diabetology
Cholesterol accumulates in the liver
Fatty liver disease with enlarged liver
Dr. Aanchal Maheshwari
Ayurveda
Take cytozen capsule twice, lavanbhasksr churan half spoon twice
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
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Name: Abbott
Address: 16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Address: 16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
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Country of origin: India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- Glucose - Postprandial
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid-19 Test (RT-PCR technique)
- LFT (Liver Function Test)
- Kidney Function Test
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid
- Vitamin B12
- C- Reactive Protein Quantitative
- Urine Culture and Sensitivity
- Serum Electrolyte
- Serum Calcium
- Creatinine
- Diabetes Screening
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hemoglobin
- Complete Haemogram
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