Hycamtin 1mg Tablet

Topotecan (1mg)

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Hycamtin 1mg Tablet is used in the treatment of ovarian cancer. It shows its working by stopping or slowing down the growth of cancer cells.

Written By Dr. Radhika Dua, MDS, BDS,
Reviewed By Dr. Shilpa Garcha, MD (Pharmacology), MBBS,
Last updated on 12 Nov 2024 | 01:09 AM (IST)

₹8003 MRP ₹82503% off

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Gurgaon

General Information

Contains

Topotecan (1mg)

Marketer

Glaxo SmithKline Pharmaceuticals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Hycamtin 1mg Tablet can be taken with or without food, but better to have it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include tiredness, vomiting, weakness, nausea, and abdominal pain. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, chills, sore throat, and severe diarrhea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. It is advised to stay hydrated while taking this medicine, to overcome diarrhea.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Hycamtin Tablet

Ovarian cancer

Benefits of Hycamtin Tablet

Ovarian cancer
Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Hycamtin 1mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but has some side effects that may be bothersome. Consult your doctor to know about ways that can help you avoid these side effects.

Side effects of Hycamtin Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Hycamtin

Tiredness
Vomiting
Weakness
Nausea
Abdominal pain
Indigestion
Decreased white blood cell count
Decreased blood cells (red cells, white cells, and platelets)
Diarrhea

How to use Hycamtin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Hycamtin 1mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Hycamtin Tablet works

Hycamtin 1mg Tablet is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.

Quick tips

Hycamtin 1mg Tablet helps treat ovarian cancer.
Swallow it whole. Do not chew, crush or break the tablet.
It may cause diarrhea. Drink plenty of fluids and inform your doctor If you experience more than three episodes of diarrhoea per day while having treatment with this medicine.
Do not drive or operate machinery as Hycamtin 1mg Tablet may cause tiredness, drowsiness or weakness.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Your doctor may get regular blood tests done to monitor your blood cells during treatment with this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.

Safety advice

Alcohol

SAFE

Consuming alcohol with Hycamtin 1mg Tablet does not cause any harmful side effects.

Pregnancy

CONSULT YOUR DOCTOR

Hycamtin 1mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

UNSAFE

Hycamtin 1mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Hycamtin 1mg Tablet may cause side effects which could affect your ability to drive.
Hycamtin 1mg Tablet can make you feel tired and this may affect your ability to drive.

Kidney

CAUTION

Hycamtin 1mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Hycamtin 1mg Tablet may be needed. Please consult your doctor.
Use of Hycamtin 1mg Tablet is not recommended in patients with end-stage kidney disease.

Liver

SAFE IF PRESCRIBED

Hycamtin 1mg Tablet is safe to use in patients with liver disease. No dose adjustment of Hycamtin 1mg Tablet is recommended.

Frequently asked questions

How often is Hycamtin 1mg Tablet given?

Generally Hycamtin 1mg Tablet treatment is for 4 cycles of 21 day each, patient is given Hycamtin 1mg Tablet for first 5 days of each cycle.

Does Hycamtin 1mg Tablet cause hair loss?

Yes, Hycamtin 1mg Tablet may cause temporary hair loss.

Does Hycamtin 1mg Tablet cause flare reaction?

Yes, Hycamtin 1mg Tablet may cause flare reaction.

How long does Hycamtin 1mg Tablet take to work?

Hycamtin 1mg Tablet may start its action once the infusion is started, however, the complete effect may be assessed only after completion of 4 cycles.

Is Hycamtin 1mg Tablet a vesicant?

Hycamtin 1mg Tablet is a vesicant (irritant).

Is Hycamtin 1mg Tablet effective?

Yes Hycamtin 1mg Tablet is effective if used at prescribed doses for the prescribed duration as advised by your doctor.

What is Hycamtin 1mg Tablet chemotherapy?

It is a treatment therapy that includes Hycamtin 1mg Tablet with or without combination of other drugs in treatment of cancer (Usually ovarian or lung cancer).

How is Hycamtin 1mg Tablet administered?

Hycamtin 1mg Tablet is either administered orally as a capsule or as an intravenous Infusion in the arm over a period of 30 min.

Fact Box

Chemical Class

Camptothecin Derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Topoisomerase Inhibitor

References

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1711-12.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 951.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1383.
Topotecan. Research Triangle Park, North Carolina: GlaxoSmithKline; 1996 [revised Oct. 2007]. [Accessed 27 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Topotecan. [Updated 2018 Dec 3]. [Accessed 19 Feb. 2020] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Glaxo SmithKline Pharmaceuticals Ltd
Address: Dr. Annie Besant Road, Mumbai - 400 030

Vendor Details

Country of origin: India

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