Isocrate 20mg Tablet
Written By Dr. Betina Chandolia, MDS, BDS
Reviewed By Dr. Shilpa Garcha, MD (Pharmacology), MBBS
Last updated on 11 Nov 2024 | 01:10 AM (IST)
Isocrate 20mg Tablet is used to prevent chest pain (angina attacks). It works by relaxing and widening blood vessels so blood can flow more easily to the heart. These tablets will not treat an angina attack that has already begun. They may be also used to control heart failure.
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General Information
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Product introduction
Isocrate 20mg Tablet should be taken on an empty stomach. It is best taken at the same time every day. Your doctor will decide the dose and the number of times each day you should take them. You should take the medicine as it is prescribed for you and keep taking it, even if you feel well. If you stop taking it suddenly your risk of an angina attack will increase. Lifestyle changes such as diet, exercise, and not smoking may help this drug work better.
You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule to prevent this from happening.
The most common side effects of this medicine include headache and lightheadedness. These may disappear once you have got used to the medicine. If you are worried, or the symptoms do not go away, let your doctor know. Some of these can be reduced by taking painkillers, drinking plenty of fluids, and avoiding alcohol. Alcohol may increase some side effects (dizziness, drowsiness, feeling light-headed, or fainting). Medical tests (such as blood pressure) may be required to monitor your progress and check for side effects.
You can develop tolerance to this medicine over time, which means that the same dose becomes less effective. You have to stick to a really specific dosing schedule to prevent this from happening.
The most common side effects of this medicine include headache and lightheadedness. These may disappear once you have got used to the medicine. If you are worried, or the symptoms do not go away, let your doctor know. Some of these can be reduced by taking painkillers, drinking plenty of fluids, and avoiding alcohol. Alcohol may increase some side effects (dizziness, drowsiness, feeling light-headed, or fainting). Medical tests (such as blood pressure) may be required to monitor your progress and check for side effects.
Uses of Isocrate Tablet
Side effects of Isocrate Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Isocrate
- Headache
How to use Isocrate Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Isocrate 20mg Tablet is to be taken empty stomach.
How Isocrate Tablet works
Isocrate 20mg Tablet is a nitrate. It works by relaxing the blood vessels which decreases the oxygen demand of the heart and reduces its workload. It thus prevents/treats attacks of angina (chest pain).
All substitutes for Isocrate 20mg Tablet
For information purposes only. Consult a doctor before taking any medicine.
Quick tips
- Eat healthy (low-fat, high-fiber, low-sodium diet), quit smoking, increase your physical activity, watch your weight and reduce stress.
- Isocrate 20mg Tablet may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
- Do not consume alcohol while taking Isocrate 20mg Tablet as it may cause increased dizziness.
- It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
- You may develop tolerance to Isocrate 20mg Tablet with time, meaning that the same dose may be less effective next time. Follow the prescribed dosing schedule to avoid this.
- Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with Isocrate 20mg Tablet as it may cause low blood pressure.
- You have been prescribed Isocrate 20mg Tablet for the prevention and treatment of heart-related chest pain (angina).
- Eat healthy (low-fat, high-fiber, low-sodium diet), quit smoking, increase your physical activity, watch your weight and reduce stress.
- Isocrate 20mg Tablet may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
- Do not consume alcohol while taking Isocrate 20mg Tablet as it may cause increased dizziness.
- It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
- You may develop tolerance to Isocrate 20mg Tablet with time, meaning that the same dose may be less effective next time. Follow the prescribed dosing schedule to avoid this.
- Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with Isocrate 20mg Tablet as it may cause low blood pressure.
Safety advice

Alcohol
UNSAFE
Consuming alcohol while taking Isocrate 20mg Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).

Pregnancy
CONSULT YOUR DOCTOR
Isocrate 20mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding
SAFE IF PRESCRIBED
Isocrate 20mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving
UNSAFE
Isocrate 20mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney
SAFE IF PRESCRIBED
Isocrate 20mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Isocrate 20mg Tablet is recommended.
However, inform your doctor if you have an underlying kidney disease.
However, inform your doctor if you have an underlying kidney disease.

Liver
SAFE IF PRESCRIBED
Isocrate 20mg Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Isocrate 20mg Tablet may not be needed in these patients. Please consult your doctor.

Frequently asked questions
Isocrate 20mg Tablet belongs to a group of medicines called organic nitrates. Isocrate 20mg Tablet is used to prevent and treat angina pectoris and as an adjunctive treatment in severe acute or chronic congestive cardiac failure.
Isocrate 20mg Tablet works by widening the blood vessels in your heart to allow an increased amount of blood flow to areas which need it.
No, Isocrate 20mg Tablet does not lower heart rate. However, in some cases, one may experience reflex tachycardia (fast heart rate) while using nitrates such as Isocrate 20mg Tablet.
Yes, Isocrate 20mg Tablet lowers blood pressure. This medicine widens the blood vessels and decreases the resistance in them, causing a fall in blood pressure. This fall in blood pressure may in turn decrease the heartbeat which can lead to angina. This medicine should be avoided in people who already have low blood pressure. Discuss with your doctor if you have any concerns.
No, you should not take sildenafil along with Isocrate 20mg Tablet. Both these medicines lower blood pressure and belong to the same class. Taking these two medicines together may cause significant decrease in blood pressure which can cause fainting or even a heart attack. Along with this, avoid taking other medicines which belong to the same class such as vardenafil and tadalafil.
Fact Box
Chemical Class
Nitrates
Habit Forming
No
Therapeutic Class
CARDIAC
Action Class
Nitric Oxide (NO) Donors
Related lab tests
References
- Opie LH, Horowitz JD. Nitrates and Newer Antianginals β-Blocking Agents. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. p. 47.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 743-44.
- Isosorbide dinitrate. Cologne, Germany: MEDA Manufacturing GmbH; 2015. [Accessed 19 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
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A licensed vendor partner from your nearest location will deliver Isocrate 20mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
A licensed vendor partner from your nearest location will deliver Isocrate 20mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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