Istamet G-IR 50/500/1 Tablet is a combination of three medicines used to lower blood glucose levels in people with type 2 diabetes mellitus. It is generally prescribed when diet, exercise, and other treatments do not result in adequate glycemic control.
Istamet G-IR 50/500/1 Tablet is best taken with food; however, take this medicine regularly and at the same time each day to get maximum benefits. The dose and duration are decided according to your condition and how well you respond to it. The doctor may also monitor your blood sugar levels regularly when you are taking this combination medicine.
Keep taking this medicine even if you feel well or your blood sugar levels are controlled. If stopped abruptly, your blood sugar levels could rise and put you at risk of complications. This medication is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction because lifestyle habits play a big part in controlling diabetes.
The most common side effects of Istamet G-IR 50/500/1 Tablet include nausea, vomiting, gastrointestinal disturbances, and hypoglycemia. Let your doctor know if any of these side effects do not go away or get worse. They may be able to help by adjusting the dosage or by prescribing an alternate medicine.
You should not take Istamet G-IR 50/500/1 Tablet if you have type 1 diabetes mellitus or acute or chronic metabolic acidosis, including diabetic ketoacidosis. Patients with active bladder cancer or a history of bladder cancer should also not take this medicine. Inform your doctor about all the other medicines that you take as some of them can affect or be affected by this medication. Pregnant or breastfeeding women should also consult their doctors before taking it.
Lowering blood glucose levels is an essential part of managing diabetes as this helps to reduce the risk of serious diabetes-associated complications, such as kidney damage, eye damage, nerve problems, and loss of limbs. Istamet G-IR 50/500/1 Tablet helps control high blood glucose (sugar) levels. It also reduces the risk of heart diseases like heart attack or stroke. Taking this medicine regularly along with proper diet and exercise will help you live a normal, healthy life.
Side effects of Istamet G Tablet IR
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Istamet G
Nausea
Vomiting
Gastrointestinal disturbance
Hypoglycemia (low blood glucose level)
How to use Istamet G Tablet IR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Istamet G-IR 50/500/1 Tablet is to be taken with food.
How Istamet G Tablet IR works
Istamet G-IR 50/500/1 Tablet is a combination of three antidiabetic medications. Sitagliptin helps to control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood. Glimepiride lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. Metformin decreases the amount of glucose you absorb from your food and the glucose made by the liver. It also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood (blood sugar levels).
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Istamet G-IR 50/500/1 Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Istamet G-IR 50/500/1 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Istamet G-IR 50/500/1 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Kidney
CAUTION
Istamet G-IR 50/500/1 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Istamet G-IR 50/500/1 Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Istamet G-IR 50/500/1 Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Istamet G-IR 50/500/1 Tablet may be needed. Please consult your doctor.
What if you forget to take Istamet G Tablet IR?
If you miss a dose of Istamet G-IR 50/500/1 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Prefer taking Istamet G-IR 50/500/1 Tablet after a meal or with a snack, as this will reduce the chance of an upset stomach.
Istamet G-IR 50/500/1 Tablet may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemia (low blood sugar) symptoms, such as fatigue, dizziness, cold sweats, tremor, and anxiety.
If you get unusually thirsty, pass urine more frequently, and feel tired, let your doctor know. These are signs that there is too much sugar in your blood and your dose may need adjusting.
Monitor your blood sugar regularly while taking this medicine.
Lifestyle changes like low sugar diet, exercising, losing weight, not smoking, and cutting down on alcohol intake may help this medication work better.
Fact Box
Habit Forming
No
Therapeutic Class
ANTI DIABETIC
Patient concerns
I am a type 2 diabetic patient. Dr. has prescsribed to take Istamet/Jalra 50/500. Can I take Zita met 50/500 inplace of Istamet/Jalra 50/500?
Dr. Sanjay Bhatt
Physician
Can take only after consult with your doctor as he knows your complete medical history and sugar level variations
My diabetes is not control and my wait is loosing again so pls suggest that Tresiba insulin, evion LC ,gemer pl 2 , gemer 1 , istamet 50/500 medilda this tablet is taken by me thanks
Dr. Sanjay Bhatt
Physician
Weight loosing is because of diabetes. Needs to take medicines regularly and do exercise regularly. Try to keep sugar level in normal limits.
Two months back detected type 2 diabetes undergoing treatment of istamet 50/ 500 twice a day before detecting i was fit and fine but now when undergoing treatment i feel drowsy no freshness feel more week why so
Dr. Sanjay Bhatt
Physician
It may be psychological effect of diabetes you have. You no need to worry about.Take medicine regularly and try to keep sugar level in normal limits. Do exercise regularly.
Uncontrolled type I. Humalog mix 25/75 prescribed But some doctor friends recomend Novomix 30/70. Pls suggest. Again pls advise Gulvasmet 50/500 vs Istamet 50/500.
Dr. Sanjay Bhatt
Physician
action of medicine changes from patient to patient.you need to give your compleate medical history and variation of blood sugar level in your body.After that a doctor can priscribe which medicine is suitable for you.so discuss with your doctor
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References
Sitagliptin/metformin HC [Prescribing Information]. Whitehouse Station: Merck & Co., Inc.; 2012. [Accessed 02 Nov. 2023] (online) Available from:
A Multicenter, Randomized, Comparative, Active-Controlled, Double-Blind, Double-Dummy, Phase 3 Study to Assess Efficacy and Safety of Fixed Dose Combination of Sitagliptin Phosphate, Metformin Hydrochloride and Glimepiride Tablets in Comparison to Co- administration of Metformin Hydrochloride and Glimepiride Tablets in Patients with Type 2 Diabetes Mellitus. Protocol No. ICR/21/004, clinical study report dated 3rd July 2023, Sun Pharma Laboratories Limited, Data on file.
Marketer details
Name: Sun Pharma Laboratories Ltd
Address: Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Country of origin: India Expires on or after: September, 2025
A licensed vendor partner from your nearest location will deliver Istamet G-IR 50/500/1 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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