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Kucil 500mg Injection

Written By Dr. Anuj Saini, MMST, MBBS
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology
Last updated on 12 Nov 2024 | 01:05 AM (IST)
Kucil 500mg Injection is used in the treatment of cancers of stomach, colon, rectum, breast, and lungs. It may be used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy.
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General Information

Contains

Fluorouracil (500mg)

Marketer

Khandelwal Laboratories Pvt Ltd

Storage

Store below 30°C
The content is shown in English
Kucil 500mg Injection image

Product introduction

Kucil 500mg Injection is given as injection under the supervision of doctor.  Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include increased risk of infection, mouth ulcer, vomiting, weakness, and nausea. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Kucil Injection

Benefits of Kucil Injection

Cancer
Kucil 500mg Injection helps to treat certain kinds of cancer such as cancer of the breasts, lungs, colon, rectum etc. It may be used alone or in combination with other medicines to treat cancer in various parts of the body. Kucil 500mg Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side effects of Kucil Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Kucil
  • Nausea
  • Vomiting
  • Hair loss
  • Diarrhea
  • Bronchospasm
  • Infection
  • Myelosuppression
  • Agranulocytosis (deficiency of granulocytes in the blood)
  • General discomfort
  • Itching
  • Skin exfoliation
  • Anemia (low number of red blood cells)
  • Febrile neutropenia
  • Angina (heart related chest pain)
  • ECG changes
  • Decreased immunity

How to use Kucil Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Kucil Injection works

Kucil 500mg Injection is an anticancer medication. It works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This slows the growth of cancer cells and eventually kills them.

Quick tips

  • Kucil 500mg Injection helps treat cancers of stomach, colon, rectum, breast, and lungs.
  • It is given as an injection into a vein, or as a drip (infusion) into a vein or artery.
  • The dose and the number of treatment cycles needed will depend on the type and stage of cancer that is being treated.
  • It may cause dizziness and visual changes. Do not drive or do anything requiring concentration until you know how it affects you.
  • Your doctor may regularly monitor your blood cells and liver function during treatment with this medicine.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Kucil 500mg Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Kucil 500mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding

Breast feeding

UNSAFE
Kucil 500mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

UNSAFE
Kucil 500mg Injection may cause side effects which could affect your ability to drive.
Kucil 500mg Injection can cause side effects such as nausea and can also produce adverse events on your nervous system which cause visual changes.This may affect your ability to drive.
Kidney

Kidney

SAFE IF PRESCRIBED
Kucil 500mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Kucil 500mg Injection may not be needed in these patients. Please consult your doctor.
Liver

Liver

CAUTION
Kucil 500mg Injection should be used with caution in patients with liver disease. Dose adjustment of Kucil 500mg Injection may be needed. Please consult your doctor.
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Frequently asked questions

No, fluorouracil is not a vesicant (irritant).
Fluorouracil is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
No, flurouracil is not a steroid.
Fluorouracil is used as chemotherapy for the treatment of cancers.
Yes, fluorouracil is used for the treatment of warts.
Efudex is a brand name (trade name) for fluorouracil.
Fluorouracil has minimal effect on the surrounding healthy skin.
Yes, fluorouracil may cause temporary hair loss.
No, fluorouracil is not known to cause scarring.
Though headache is not a common side effect of fluorouracil, it may occur uncommonly is some people.
As with any chemotherapy for cancer, fluorouracil causes fatigue which is attributed to be of multi-factor origin, but inflammation and anemia are thought to be the most important factors.

Fact Box

Chemical Class

Pyrimidine Analog

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Antimetabolites

References

  1. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 946-47.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 561-63.
  3. Fluorouracil. Hurley, Maidenhead: Hospira UK Ltd.; 1985 [revised Jan. 2017]. [Accessed 29 Jan. 2019] (online) Available from:
  4. Drugs.com. Fluorouracil Pregnancy and Breastfeeding Warnings. [Accesses on 27 Mar. 2019] (online) Available from:
  5. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Fluorouracil. [Updated 2018 Dec 3]. [Accessed 18 Feb. 2020] (online) Available from:
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
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Patient concerns

Sir my brother have skin cancer can you do something for save his life ??

Dr. Sanjay Singh Rai
Dr. Sanjay Singh Rai
Medical Oncology and Hematology
Treatment of cancer depends on whether it is localized or metastatic cancer

How we can find out parient is CA and which report we can do for know the patient is CA

Dr. Sanjay Singh Rai
Dr. Sanjay Singh Rai
Medical Oncology and Hematology
Thr is no single test for cancerWhich cancer ur looking for
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Khandelwal Laboratories Pvt Ltd
Address: KHANDELWAL LABORATORIES PVT. LTD, 79/87 D.LADPATH, MUMBAI 400 033, INDIA

Vendor Details

Country of origin: India

Lab tests offered by us

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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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