Methotin 5mg Tablet

Reviewed By Dr. Shilpa Garcha, MD (Pharmacology), MBBS

Last updated on 11 Nov 2024 | 01:07 AM (IST)

Methotin 5mg Tablet is a medicine used for treatment of cancer in various parts of the body such as breasts, head, neck, lungs, blood, bone, lymph, and uterus. It is also used to treat rheumatoid arthritis, severe and uncontrolled psoriasis, and Crohn’s disease.

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1/2

10 tablets

General Information

Contains

Methotrexate (5mg)

Marketer

TNT Lifesciences

Storage

Store below 30°C

The content is shown in English

Product introduction

Methotin 5mg Tablet may be used alone or in combination with other medicines. You should take it exactly as your doctor has advised. Taking too much of it can cause serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid consumption of alcohol while taking this medicine as it may increase your risk of liver damage.

The most common side effects of this medicine are ulcerative stomatitis, hairloss, low blood cell count, increased liver enzymes, nausea, and abdominal distress. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. This medicine may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor may perform several tests such as blood tests, X-rays, and physical examinations both before and during treatment with this medicine to check for these.

Before taking it, tell your doctor if you have problems related to the stomach, liver, or kidney, or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding as it may harm the baby.

Uses of Methotin Tablet

Benefits of Methotin Tablet

Treatment of Cancer
Methotin 5mg Tablet works by slowing the growth of cancer cells in the body. It is used to treat a wide range of cancers such as acute leukemias, non-Hodgkin’s lymphoma, and solid tumors found in breast, lung, bladder, head and neck as well as cervical, ovarian and testicular cancer. It may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Treatment of Rheumatoid arthritis
Methotin 5mg Tablet belongs to a group of medicines called antimetabolites. It may be used to treat severe rheumatoid arthritis if other treatments have already been tried and have not worked. It is not a first-line treatment. It works by reducing the body's immune system, this decreases swelling, reduces pain, stiffness, and improves function. Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. Do not take more than you should. It may take several months to become fully effective.

Treatment of Psoriasis
Methotin 5mg Tablet belongs to a group of medicines called antimetabolites. It may be used to treat severe psoriasis when other treatments have not worked. Psoriasis is a condition where the skin cells in the body grow too quickly. Methotin 5mg Tablet works by killing these fast-growing cells. It is potent and very toxic medicine and you should discuss the risks and benefits with your doctor. Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. DO NOT take more than you should. It may take several months to become fully effective. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Treatment of Crohn’s disease
Crohn’s disease is a chronic (long-term) inflammatory disease of the intestines. The most common symptoms are diarrhea and pain in your abdomen. Methotin 5mg Tablet helps reduce the inflammation, relieve the symptoms, and prevent them from coming back.

Side effects of Methotin Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Methotin

Ulcerative stomatitis
Nausea
Abdominal pain
Increased liver enzymes
Hair loss
Decreased blood cells (red cells, white cells, and platelets)

How to use Methotin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Methotin 5mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Methotin Tablet works

Methotin 5mg Tablet inhibits enzymes (dihydrofolate reductase), prevents cell division and leads to anti-inflammatory actions. Methotin 5mg Tablet kills cancer cells by preventing them from making DNA. Methotin 5mg Tablet can help control psoriasis by retarding the production of skin cells and suppressing inflammation. Methotin 5mg Tablet may treat rheumatoid arthritis by suppressing the immune system, preventing it from attacking the body's cells. This helps reduce the inflammation that causes swollen and stiff joints in rheumatoid arthritis, or damage to bowel in Crohn's disease.

All substitutes for Methotin 5mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Drink plenty of liquids to stay hydrated while taking this medication.
Take folic acid if advised by your doctor. This will help lessen the side effects of this medicine.
It may take from weeks to months for Methotin 5mg Tablet to work. Keep taking the medication as prescribed.
Your doctor may get regular blood test done to monitor your kidney function, liver function and level of blood cells in your blood.
Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Methotin 5mg Tablet.

Pregnancy

UNSAFE

Methotin 5mg Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

UNSAFE

Methotin 5mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Methotin 5mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Methotin 5mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Methotin 5mg Tablet may be needed. Please consult your doctor.
Regular monitoring of kidney function test is advised while you are taking this medicine.

Liver

CAUTION

Methotin 5mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Methotin 5mg Tablet may be needed. Please consult your doctor.

Frequently asked questions

Can Methotin 5mg Tablet cause mouth ulcers?

Yes, Methotin 5mg Tablet can cause a sore mouth and mouth ulcers as side effects in some cases. Taking folic acid along with this medicine may help in reducing the ulcers. Ask your doctor if the dose can be reduced as dose reduction may further help in reducing the ulcers.

Why do I have to take folic acid with Methotin 5mg Tablet?

Folic acid is required to make new cells in the body and Methotin 5mg Tablet decreases the folic acid levels in the body. Folic acid can help reduce some of the common side effects of Methotin 5mg Tablet such as mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia and liver problems.

Why do I need to take regular blood tests while taking Methotin 5mg Tablet?

Regular blood tests will help your doctor to check your response to Methotin 5mg Tablet and monitor you for side effects. You will need to regularly check your liver function and your blood counts (white blood cells, red blood cells and platelets). Your doctor may also order additional tests depending on the results.

Can Methotin 5mg Tablet use make me more prone to infections?

Methotin 5mg Tablet may decrease the activity of your immune system. As a result, you may develop serious infections. There have been rare reports which suggest occurrence of serious lung infections with Methotin 5mg Tablet use. If you have an active infection, Methotin 5mg Tablet should be used with extreme caution.

Can Methotin 5mg Tablet affect fertility?

Yes, Methotin 5mg Tablet may affect fertility in both males and females. It may cause a decrease in sperm count in males and menstrual disturbances in females. No need to worry, these effects are reversible and disappear once the therapy is discontinued.

What to do if I am planning to become pregnant and my husband is taking Methotin 5mg Tablet?

You should avoid pregnancy if your husband is taking Methotin 5mg Tablet. Also, it is advised that pregnancy should be further avoided for a minimum of 3 months after the therapy as it can lead to serious fetal abnormalities.

Fact Box

Chemical Class

Glutamic Acid Derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Antimetabolite- Methotrexate

Related lab tests

Anti Saccharomyces Cerevisiae (ASCA), IgA

Anti Saccharomyces Cerevisiae (ASCA), IgG

Rheumatoid Factor - Agglutination

Rheumatoid Factor - Turbidometry

Rheumatoid Factor IgG Antibody

References

Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 944-46.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 887-90.
Methotrexate [Prescribing Information]. Eatontown, NJ: West-Ward Pharmaceuticals Corp.; 2020. [Accessed 19 Apr. 2023] (online) Available from:
Methotrexate [Product Label]. New York, NY: Pfizer Inc.; 2022. [Accessed 19 Apr. 2023] (online) Available from:
Methotrexate [Drug Label]. Sandton, South Africa: Pfizer Laboratories (Pty) Ltd.; 2022 [Accessed 19 Apr. 2023] (online) Available from:
Walfish AE, Companioni RA. Drugs for Inflammatory Bowel Disease. [Updated Sep. 2022]. [Accessed 19 Apr. 2023] (online) Available from:
Crohn's & Colitis, UK. Methotrexate [Information Sheet]. [Accessed 19 Apr. 2023] (online) Available from:
CiplaMed. Methotrexate [Prescribing Information]. [Last Reviewed: Feb 2019]. [Accessed 11 Jul. 2023]. (online) Available from:

Patient concerns

Sir/Ma'am, I feel pain in the heel of both the legs especially when I get up from the bed in the morning. After walking couple of steps, it goes away. there is no bone problem reported in the Xray report. Please guide me what could be the reason?

Dr. Mehtab Baig

Orthopaedic Physiotherapy

This is the test for rheumatoid arthritis

I have joint pain in my rt wrist since 6 yrs. What are the possible reasons?

Dr. Trilok Kumar Jha

Orthopaedics

It may be Tenosynovitis, or Rheumatoid arthritis or any other type of arthritis

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: TNT Lifesciences
Address: Address : Plot No-110, Industrial Area, Phase-2, Panchkula New Delhi 134113 India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Methotin 5mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Methotin 5mg Tablet

General Information

Contains

Marketer

Storage

Product introduction

Uses of Methotin Tablet

Benefits of Methotin Tablet

Side effects of Methotin Tablet

How to use Methotin Tablet

How Methotin Tablet works

All substitutes for Methotin 5mg Tablet

Oncotrex 5 Tablet

Meditrex 5mg Tablet

Mexate 5 Tablet

Mtx 5mg Tablet

Trexo 5mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

Can Methotin 5mg Tablet cause mouth ulcers?

Why do I have to take folic acid with Methotin 5mg Tablet?

Why do I need to take regular blood tests while taking Methotin 5mg Tablet?

Can Methotin 5mg Tablet use make me more prone to infections?

Can Methotin 5mg Tablet affect fertility?

What to do if I am planning to become pregnant and my husband is taking Methotin 5mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Anti Saccharomyces Cerevisiae (ASCA), IgA

Anti Saccharomyces Cerevisiae (ASCA), IgG

Rheumatoid Factor - Agglutination

Rheumatoid Factor - Turbidometry

Rheumatoid Factor IgG Antibody

References

Patient concerns

Sir/Ma'am, I feel pain in the heel of both the legs especially when I get up from the bed in the morning. After walking couple of steps, it goes away. there is no bone problem reported in the Xray report. Please guide me what could be the reason?

I have joint pain in my rt wrist since 6 yrs. What are the possible reasons?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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