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Nex 400mcg Injection

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology
Last updated on 12 Nov 2024 | 01:07 AM (IST)
Nex 400mcg Injection is an opioid antagonist. It is used for the treatment of opioid toxicity. It helps to reverse the depressant effect on breathing, and on other parts of the body. It also helps to determine if a patient has taken an overdose of opioids.
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General Information

Contains

Naloxone (400mcg)

Marketer

Neon Laboratories Ltd

Storage

Store below 30°C
The content is shown in English
Nex 400mcg Injection image

Product introduction

Nex 400mcg Injection is given as an injection into veins, muscle, or under the skin by a doctor or nurse. It is advisable not to self-administer the injection. Your doctor or nurse will train your family member or caregiver about how to inject the medicine in case of an emergency. It is advisable to follow your doctor's advice while being on the treatment. 

The most common side effects of this medicine include injection site redness, dizziness, headache and increased or decreased blood pressure. Most of these usually go away within a short time of the injection. If you are bothered by them or they go on for longer, talk to your doctor or nurse. You should not drive if this medicine makes you feel dizzy. 

Before taking it, tell your doctor if you have heart problems, high blood pressure, or high heart rate. This may affect your treatment. Pregnant or breastfeeding women should consult their doctor before taking this medicine.  Some other medicines you are taking may interfere with it, so make sure your doctor knows about all the other medicines you are using.

Uses of Nex Injection

  • Opioid toxicity

Benefits of Nex Injection

Opioid toxicity
Opioid toxicity or opioid overdose can be life-threatening and requires immediate medical attention. It is most commonly seen in people who take opioids containing painkillers or those who are indulged in drug abuse. Nex 400mcg Injection helps to reverse the effects of opioid toxicity such as reduced breathing, confusion, lessened alertness, and loss of consciousness.
Nex 400mcg Injection is given as an injection by a doctor or a nurse and should not be self-administered. If you are a caregiver to a person who is on opioids, you need to be trained well by a healthcare professional to administer Nex 400mcg Injection in case there is an emergency and you do not have access to medical services immediately.

Side effects of Nex Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Nex
  • Dizziness
  • Injection site redness
  • Decreased blood pressure
  • Headache
  • High blood pressure

How to use Nex Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Nex Injection works

Nex 400mcg Injection is an opioid antagonist. Opioid medicines are strong painkillers, which in high doses can cause life-threatening side effects such as difficulty in breathing. Nex 400mcg Injection works by blocking the effects of opioids leading to reversal of these side effects.

Quick tips

  • It is given as an injection into veins, muscle or under the skin by the healthcare professionals only.
  • Nex 400mcg Injection might make you feel dizzy. If this happens, avoid driving or operating on machinery.
  • Inform the doctor if you are taking any pain killers, sleeping pills (sedatives), narcotic painkillers, or other medicines
  • Avoid consuming alcohol while taking the medicine as it can affect the working of the medicine.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Nex 400mcg Injection.
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Nex 400mcg Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Nex 400mcg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving

Driving

SAFE
Nex 400mcg Injection does not usually affect your ability to drive.
Kidney

Kidney

SAFE IF PRESCRIBED
Nex 400mcg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Nex 400mcg Injection may not be needed in these patients. Please consult your doctor.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited information available on the use of Nex 400mcg Injection in patients with liver disease. Please consult your doctor.
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Fact Box

Chemical Class

Phenanthrenes derivatives

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Opioid Antagonist

Related lab tests

Opiates

References

  1. Yaksh TL, WallaceIn MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 512.
  2. Schumacher MA, Basbaum AI, Way WL. Opioids Analgesics & Antagonists. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 547-48.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 952-53.
  4. Naloxone hydrochloride dihydrate. King William Street, London: Advanz Pharma; 1990 [revised 30 Aug. 2012]. [Accessed 6 Apr. 2019] (online) Available from:
  5. Medscape. Naloxone. [Accessed 6 Apr. 2019] (online) Available from:
  6. Drugs.com. Naloxone injection. [Accessed 06 Apr. 2019] (online) Available from:
  7. Naloxone. Richmond: Kaleo, Inc.; 1971 [revised Apr. 2014]. [Accessed 6 Apr. 2019] (online) Available from:
  8. Central Drugs Standard Control Organisation (CDSCO). [Accessed 6 Apr. 2019] (online) Available from:
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Patient concerns

Powerful medicine for erection dysfunction. pl suggest. Diabetic, bp long 20 years.

Dr. Aanchal Maheshwari
Dr. Aanchal Maheshwari
Ayurveda
It should be confirmed that your Bp and sugar must be under control. Take 1 spoon urad daal and soak it in water, nex day grindit into a paste and boil it well in milk. Take this first thing in morning.als0 take 1 spoon ashwgandha powder twice with milk.

Is there any toxic effect for the drug garoin(phenobarbitone and phenytoin) in constipation child If the child doesnot having epilepsy also??

Dr. Gopal Samdani
Dr. Gopal Samdani
Paediatrics
Toxicity is dose dependent
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Neon Laboratories Ltd
Address: 140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.

Vendor Details

Country of origin: India

Lab tests offered by us

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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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