Nitrogesic Rectal Ointment
Written By Dr. Radhika Dua, MDS, BDS
Reviewed By Dr. Shilpa Garcha, MD (Pharmacology), MBBS
Last updated on 12 Nov 2024 | 01:12 AM (IST)
Nitrogesic Rectal Ointment is a medicine used for relieving the pain associated with anal fissures (tear in the lining of the anus). It improves blood flow and reduces the pressure in anal tissues. This promotes healing of fissures and relieves pain.
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General Information
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Product introduction
Nitrogesic Rectal Ointment is for external use only. Use it in the dose and duration as advised by your doctor. Clean and dry the affected area and gently apply it over the affected area. Do not get it into your mouth, eyes, or nose. In case of accidental contact, rinse it thoroughly with clean water.
On using this medicine, some people may experience headache. You may also experience slight anal irritation upon application of the medicine. This is temporary and usually resolves on its own in some time. You should consult your doctor if it does not resolve or persists for a longer duration.
Do not use the medicine if you are taking medicines to treat high blood pressure in your lungs (pulmonary hypertension), or if you have anemia or glaucoma (increased pressure inside the eye). Always tell your doctor what other health conditions you have and what other medicines you are taking. If you are pregnant, thinking about becoming pregnant, or breastfeeding, ask your doctor before taking this medicine.
On using this medicine, some people may experience headache. You may also experience slight anal irritation upon application of the medicine. This is temporary and usually resolves on its own in some time. You should consult your doctor if it does not resolve or persists for a longer duration.
Do not use the medicine if you are taking medicines to treat high blood pressure in your lungs (pulmonary hypertension), or if you have anemia or glaucoma (increased pressure inside the eye). Always tell your doctor what other health conditions you have and what other medicines you are taking. If you are pregnant, thinking about becoming pregnant, or breastfeeding, ask your doctor before taking this medicine.
Uses of Nitrogesic Rectal Ointment
Side effects of Nitrogesic Rectal Ointment
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Nitrogesic
- Headache
- Application site reactions (burning, irritation, itching and redness)
How to use Nitrogesic Rectal Ointment
This medicine is for external use only. Use it in the dose and duration as advised by your doctor.
How Nitrogesic Rectal Ointment works
Nitrogesic Rectal Ointment works by relaxing the muscles around the blood vessels which reduces pressure inside the anus and relieves pain. This treats pain associated with anal fissures, hemorrhoids, and hemorrhoidectomy.
Quick tips
- Nitrogesic Rectal Ointment may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
- Do not consume alcohol while taking Nitrogesic Rectal Ointment as it may cause increased dizziness.
- It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
- You may develop tolerance to Nitrogesic Rectal Ointment with time, meaning that the same dose may be less effective next time. Follow the prescribed dosing schedule to avoid this.
- Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with Nitrogesic Rectal Ointment as it may cause low blood pressure.
- You have been prescribed Nitrogesic Rectal Ointment for the prevention and treatment of heart-related chest pain (angina).
- Eat healthy (low-fat, high-fiber, low-sodium diet), quit smoking, increase your physical activity, watch your weight and reduce stress.
- Nitrogesic Rectal Ointment may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
- Do not consume alcohol while taking Nitrogesic Rectal Ointment as it may cause increased dizziness.
- It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
- You may develop tolerance to Nitrogesic Rectal Ointment with time, meaning that the same dose may be less effective next time. Follow the prescribed dosing schedule to avoid this.
- Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with Nitrogesic Rectal Ointment as it may cause low blood pressure.
Safety advice

Alcohol
No interaction found/established

Pregnancy
CONSULT YOUR DOCTOR
Nitrogesic Rectal Ointment may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding
SAFE IF PRESCRIBED
Nitrogesic Rectal Ointment is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving
No interaction found/established

Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Nitrogesic Rectal Ointment in patients with kidney disease. Please consult your doctor.

Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Nitrogesic Rectal Ointment in patients with liver disease. Please consult your doctor.

Frequently asked questions
No, Nitrogesic Rectal Ointment does not cure fissures. It reduces inflammation of mucous membrane and skin. It also helps to reduce irritation, pain and itching associated with anal fissures, thus providing symptomatic relief.
Fissures usually heal within a few weeks. But if your fissures do not improve then this could be due to the poor oxygen supply to the area being treated which further slows down the healing process. As a result, these fissures fail to heal and continue to get worse. You should consult a doctor immediately if you have been facing issues for a duration longer than a few weeks.
You must take a fiber-rich diet such as vegetables, fresh fruits and whole grains if you have fissures. Drink plenty of water and avoid taking alcohol. This will ensure that your stools are soft and easy to pass. You can also take laxatives or fiber supplements if you are facing issues with digestion. Your doctor will suggest ways to avoid constipation and thereby promote healing of fissures.
No, spicy foods do not cause fissures. But, they can irritate the fissures and worsen your symptoms. Therefore, it is advised that you avoid taking spicy foods if you are facing issues with your fissures.
Follow your doctor’s instructions before using Nitrogesic Rectal Ointment. Apply a small amount of the ointment to the affected rectal area as directed. If this is to be used inside the rectum, attach the rectal applicator onto the tube. Insert the applicator gently and to full extent into the rectum. Gently squeeze the tube to deliver the medication while withdrawing it.
Fissures usually heal within a few weeks. But, if they persist for longer than 4 to 6 weeks, they are termed as chronic fissures. Please consult your doctor without any delay if you have been noticing fissures for longer than 4 weeks.
Be careful not to get Nitrogesic Rectal Ointment into your eyes or mouth. If you happen to get it in your eyes, rinse off with plenty of water immediately and contact your doctor. You must not use Nitrogesic Rectal Ointment if you are allergic to it or any of its ingredients. Tell your doctor if you notice any allergic reaction while using it for the first time. Inform your doctor if you are taking any medicines regularly to prevent any allergic reaction with other medicines. Do not cover the area being treated with Nitrogesic Rectal Ointment with a bandage, as this may increase absorption of this medicine and increase the side effects. Do not use more than what is recommended to relieve your symptoms faster. Using more than what is advised will only increase the side effects. Let your doctor know if you are planning to conceive. Pregnant and breastfeeding mothers should use Nitrogesic Rectal Ointment only if prescribed by the doctor.
Fact Box
Chemical Class
Nitrates {Short acting}
Habit Forming
No
Therapeutic Class
GASTRO INTESTINAL
Action Class
Nitric Oxide (NO) Donors
Related lab tests
References
- Michel T, Hoffman BB. Treatment of Myocardial Ischemia and Hypertension. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 747-55.
- Katzung BG, Chatterjee K. Vasodilator & the Treatment of Angina Pectoris. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 191, 195-97.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 986-88.
- Glyceryl trinitrate. Galashiels, Scotland: Kyowa Kirin Ltd.; 2009 [revised May 2016]. [Accessed 26 Jun. 2020] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Nitroglycerin. [Updated 2018 Oct 31]. [Accessed 19 Feb. 2020] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
- Glyceryl trinitrate ointment [New Zealand Consumer Medicine Information]. Auckland, New Zealand: Pharmacy Retailing (NZ) Ltd.; 2017. [Accessed 02 Aug. 2023] (online) Available from:

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User feedback
Once A Day
45%
Twice A Day
38%
Thrice A Day
14%
Four Times A Day
3%
Anal fissure
72%
Others
21%
Chest pain (Angina)
3%
Coronary artery disease
3%
Poor
42%
Average
39%
Excellent
19%
Headache
60%
No Side Effect
20%
Nausea
10%
Dizziness
10%
With or without food
50%
Empty stomach
33%
With food
17%
Average
52%
Not Expensive
48%
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Troikaa Pharmaceuticals Ltd
Address: Troikaa Pharmaceuticals Ltd., Registered Office: , 'Commerce House - 1', Satya Marg, Bodakdev, Ahmedabad-380 054. Gujarat, India.
Address: Troikaa Pharmaceuticals Ltd., Registered Office: , 'Commerce House - 1', Satya Marg, Bodakdev, Ahmedabad-380 054. Gujarat, India.
Vendor Details
Country of origin: India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- Glucose - Postprandial
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid-19 Test (RT-PCR technique)
- LFT (Liver Function Test)
- Kidney Function Test
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid
- Vitamin B12
- C- Reactive Protein Quantitative
- Urine Culture and Sensitivity
- Serum Electrolyte
- Serum Calcium
- Creatinine
- Diabetes Screening
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hemoglobin
- Complete Haemogram
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