P-Ppi Injection
Written By Dr. Shreya Gupta, MDS (Oral Pathology & Microbiology), BDS
Reviewed By Dr. Varun Gupta, MD Pharmacology, MBBS
Last updated on 12 Nov 2024 | 01:07 AM (IST)
P-Ppi Injection is a medicine that reduces the amount of acid produced in your stomach. It is used for treating acid-related diseases of the stomach and intestine such as acid reflux, peptic ulcer disease, Zollinger-Ellison syndrome. It provides relief from symptoms and promotes healing.
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General Information
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Product introduction
P-Ppi Injection is also used to prevent stress ulcers in seriously ill patients and is administered before anesthetic medication to help prevent aspiration-related complications. It belongs to a class of medicines known as proton pump inhibitors (PPIs). This medicine is administered into a vein by a healthcare professional and will only be given to you if your doctor thinks that an injection is more suitable for you at the moment than a tablet. The dose will depend on your underlying condition and how you respond to the medicine. Your doctor will decide the duration of treatment but you should keep on taking it as prescribed, even if your symptoms disappear quickly. You can increase the efficiency of the treatment by eating smaller meals more often and avoiding caffeinated drinks (like tea and coffee), and spicy or fatty foods.
The most common side effects observed with this medicine include nausea, vomiting, headache, dizziness, flatulence, diarrhea, stomach pain, and thrombophlebitis (pain, redness, and swelling of the vein). These symptoms are generally mild but if they bother you or do not go away, consult your doctor. Long-term use of this medicine may lead to an increased risk of side effects. For instance, using this medicine for more than 1 year may increase your risk for bone fractures, especially with higher doses. Talk to your doctor about ways to prevent bone loss (osteoporosis), like taking calcium and vitamin D supplements.
P-Ppi Injection is not suitable for some people. Before taking this medicine, you need to tell your doctor if you have severe liver problems, are taking medicines for HIV, have ever had an allergic reaction to similar medicines in the past, or suffer from bone loss (osteoporosis). Pregnant or breastfeeding women should also consult their doctor before taking it. Avoid drinking alcohol as it makes your stomach produce excessive acid and can worsen your symptoms. Do not drive or use machinery or tools, if this medicine makes you feel dizzy or sleepy.
The most common side effects observed with this medicine include nausea, vomiting, headache, dizziness, flatulence, diarrhea, stomach pain, and thrombophlebitis (pain, redness, and swelling of the vein). These symptoms are generally mild but if they bother you or do not go away, consult your doctor. Long-term use of this medicine may lead to an increased risk of side effects. For instance, using this medicine for more than 1 year may increase your risk for bone fractures, especially with higher doses. Talk to your doctor about ways to prevent bone loss (osteoporosis), like taking calcium and vitamin D supplements.
P-Ppi Injection is not suitable for some people. Before taking this medicine, you need to tell your doctor if you have severe liver problems, are taking medicines for HIV, have ever had an allergic reaction to similar medicines in the past, or suffer from bone loss (osteoporosis). Pregnant or breastfeeding women should also consult their doctor before taking it. Avoid drinking alcohol as it makes your stomach produce excessive acid and can worsen your symptoms. Do not drive or use machinery or tools, if this medicine makes you feel dizzy or sleepy.
Uses of P-Ppi Injection
- Acidity
- Gastroesophageal reflux disease (Acid reflux)
- Peptic ulcer disease
- Treatment of Zollinger-Ellison syndrome
Benefits of P-Ppi Injection
Treatment of Zollinger-Ellison syndrome
Zollinger-Ellison syndrome is a rare disorder where excessive stomach acid production leads to multiple peptic ulcers. Symptoms include abdominal pain, diarrhea, and heartburn. P-Ppi Injection By reducing the production of stomach acid, it helps alleviate symptoms such as abdominal pain, heartburn, and diarrhea. Esomeprazole also aids in the healing of peptic ulcers, which are common in this condition. By controlling the excessive acid secretion associated with Zollinger-Ellison syndrome, esomeprazole helps improve the overall digestive health and prevents complications such as gastrointestinal bleeding.
Zollinger-Ellison syndrome is a rare disorder where excessive stomach acid production leads to multiple peptic ulcers. Symptoms include abdominal pain, diarrhea, and heartburn. P-Ppi Injection By reducing the production of stomach acid, it helps alleviate symptoms such as abdominal pain, heartburn, and diarrhea. Esomeprazole also aids in the healing of peptic ulcers, which are common in this condition. By controlling the excessive acid secretion associated with Zollinger-Ellison syndrome, esomeprazole helps improve the overall digestive health and prevents complications such as gastrointestinal bleeding.
Side effects of P-Ppi Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of P-Ppi
- Diarrhea
- Flatulence
- Headache
- Joint pain
- Nausea
- Stomach pain
- Vomiting
- Dizziness
- Thrombophlebitis
How to use P-Ppi Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How P-Ppi Injection works
P-Ppi Injection is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which in turn relieves acid-related indigestion and heartburn.
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Quick tips
- It is given as an injection into the veins under the supervision of the doctor.
- It is a well-tolerated medicine and provides relief for a long time.
- Some healthy tips to prevent acidity from happening:
- Avoid excessive intake of carbonated beverages/soft drinks, citrus juices, fried food, caffeinated beverages like tea and coffee.
- Avoid alcohol and smoking.
- Avoid eating late at night or before bedtime.
- Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away.
- Long-term use of P-Ppi Injection can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.
- Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem.
- P-Ppi Injection should be taken 1 hour before a meal, preferably in the morning.
- It is a well-tolerated medicine and provides relief for a long time.
- Some healthy tips to prevent acidity from happening:
- Avoid excessive intake of carbonated beverages/soft drinks, citrus juices, fried food, caffeinated beverages like tea and coffee.
- Avoid alcohol and smoking.
- Avoid eating late at night or before bedtime.
- Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away.
- Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.
- Long-term use of P-Ppi Injection can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.
- Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem.
Safety advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with P-Ppi Injection.

Pregnancy
CONSULT YOUR DOCTOR
P-Ppi Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding
SAFE IF PRESCRIBED
P-Ppi Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving
CONSULT YOUR DOCTOR
It is not known whether P-Ppi Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney
SAFE IF PRESCRIBED
P-Ppi Injection is safe to use in patients with kidney disease. No dose adjustment of P-Ppi Injection is recommended.

Liver
CAUTION
P-Ppi Injection should be used with caution in patients with severe liver disease. Dose adjustment of P-Ppi Injection may be needed. Please consult your doctor.
Frequently asked questions
P-Ppi Injection is used for the treatment of peptic ulcer disease, reflux esophagitis or gastroesophageal reflux disease (GERD). P-Ppi Injection prevents acidity associated with use of painkillers. It is also used to treat a disease associated with excessive acid production in the stomach known as Zollinger Ellison syndrome (ZES). It works by reducing the amount of acid made by your stomach and thus relieves your symptoms.
Yes, you can take antacids along with P-Ppi Injection. Take it 2 hours before or after you take P-Ppi Injection.
You should start to feel better within 2 to 3 days. It may take up to 4 weeks for P-Ppi Injection to work properly so you may still have some symptoms during this time.
Although rare but long-term treatment with P-Ppi Injection may cause weight gain. The reason could be the relief from reflux symptoms which could make you eat more. Consult your doctor for any weight-related concern.
No, alcohol intake is not advised with P-Ppi Injection. Alcohol itself does not affect the working of P-Ppi Injection, but it can increase the acid production. This may further cause worsening of your symptoms.
P-Ppi Injection is best taken 1 hour before a meal. You should avoid spicy and fatty foods while taking this medicine. You must refrain from caffeinated drinks such as tea, coffee and cola. Alcohol intake should also be avoided as it may worsen your symptoms.
P-Ppi Injection is usually prescribed for short term use only. However, if need arises, such as for treating peptic ulcer disease and Zollinger Ellison syndrome (ZES), P-Ppi Injection may be prescribed for a long term duration as well. Long term use may carry an increased risk for side effects and must be discussed with the doctor. Please use P-Ppi Injection as advised by your doctor and under their supervision.
Yes, it is safe to take painkillers along with P-Ppi Injection. P-Ppi Injection prevents acidity and stomach ulcers associated with the intake of painkillers. P-Ppi Injection is taken 1 hour before a meal. On the other hand, painkillers are usually taken with, or after a meal to avoid stomach upset.
No, a single dose may not be sufficient. However, with only a few doses of P-Ppi Injection you may get relief with the symptoms. P-Ppi Injection is usually needed only for a short term or upto 2 weeks for heartburn, indigestion, acid reflux. However, if need arises, such as for treating peptic ulcer disease and Zollinger Ellison syndrome (ZES), P-Ppi Injection may be prescribed for a long term duration as well. Please consult your doctor if you do not feel better even after taking P-Ppi Injection regularly for 2 weeks as prescribed.
If P-Ppi Injection is used for more than 3 months, certain long term side effects may be seen. The most important of these is low magnesium levels in your blood which may make you feel tired, confused, dizzy, shaky or dizzy. You may also have muscle twitches or irregular heartbeat. If the use is further prolonged for more than a year, you may have an increased risk of bone fractures, stomach infections and vitamin B12 deficiency. Vitamin B12 deficiency can make you anemic, as a result of which you may feel more tired, weak, or pale. Additionally you may have palpitations, shortness of breath, lightheadedness, indigestion, loss of appetite, flatulence (gas) or nerve problems such as numbness, tingling and problem in walking.
Fact Box
Chemical Class
Sulfinylbenzimidazole Derivative
Habit Forming
No
Therapeutic Class
GASTRO INTESTINAL
Action Class
Proton-Pump Inhibitors
References
- Wallace JL, Sharkey KA. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: The McGraw-Hill Companies, Inc.; 2011. [Accessed 24 Jan. 2019] (online) Available from:
- Pantoprazole. Philadelphia, PA: Wyeth Laboratories; [Accessed on 28 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). Pantoprazole. [Accessed 28 Mar. 2019] (online) Available from:
- Pantoprazole [Product Information]. Sydney, Australia: Takeda Pharmaceuticals Australia Pty Ltd.; 2022. [Accessed 03 Aug. 2023] (online) Available from:
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Patient concerns
Throat infection from neck to chest jalan and chest pain
Dr. Shubhra Chandhan Pradhan
ENT
It can be acid reflux. Take PPI like pantoprazole
I am suffering from heavy coughing at night somehow from 3 weeks. During starting 2-3 days it was a very sore throat, i was not able to speak even.While coughing Initially it is a dry cough but after coughing sometime, it comes with mucus. It stops automatically when I vomit or after 10-15 mins. Or after it becomes chronic. I have taken azithromycin 6 tabs. And also taken fynal oz, dilosyn syrup and doxomax-12tabs.each after consulting a doctor. Doctor told it is a throat infection. During the course of fynal oz and doxomax, I felt okay. But after the course i.e from yesterday, the cough is back. I don't understand the possible cause. I am a smoker since 2 years (not heavy smoker, generally 2-3 cigarettes/day). Bt since the problem started, I have quit smoking.
Dr. Shubhra Chandhan Pradhan
ENT
It can be allergic cough or asthma or acid reflux. Try antihistamine and ppi.
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Blue Cross Laboratories Ltd
Address: Peninsula Chambers, Peninsula Corporate Park, G.K Marg, Lower Parel (West), Mumbai - 400013, Maharashtra, INDIA.
Address: Peninsula Chambers, Peninsula Corporate Park, G.K Marg, Lower Parel (West), Mumbai - 400013, Maharashtra, INDIA.
Vendor Details
Country of origin: India
A licensed vendor partner from your nearest location will deliver P-Ppi Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
A licensed vendor partner from your nearest location will deliver P-Ppi Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- Glucose - Postprandial
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid-19 Test (RT-PCR technique)
- LFT (Liver Function Test)
- Kidney Function Test
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid
- Vitamin B12
- C- Reactive Protein Quantitative
- Urine Culture and Sensitivity
- Serum Electrolyte
- Serum Calcium
- Creatinine
- Diabetes Screening
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hemoglobin
- Complete Haemogram
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