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Phesgo 600mg/600mg Solution for Injection

Pertuzumab (600mg)+ Trastuzumab (600mg)
Genuine
Authenticity Assured
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required
Phesgo 600mg/600mg Solution for Injection is used to treat breast cancer. It works by killing the cancer cells and also prevents their further growth.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 12 Nov 2024 | 01:10 AM (IST)
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10 ml Solution for Injection
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General Information

Contains

Pertuzumab (600mg)+ Trastuzumab (600mg)

Marketer

Roche Products India Pvt Ltd
The content is shown in English
Phesgo 600mg/600mg Solution for Injection image
Phesgo 600mg/600mg Solution for Injection image

Product introduction

Phesgo 600mg/600mg Solution for Injection is given as an injection into veins under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Hair loss, diarrhea, nausea, fatigue, and arthralgia are some common side effects of this medicine. This medicine may reduce the number of blood cells (decrease white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with the heart, liver, and kidney.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

There is a Patient Support Program / Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details.

Uses of Phesgo Solution for Injection

Benefits of Phesgo Solution for Injection

Breast cancer
Phesgo 600mg/600mg Solution for Injection is used to treat breast cancer when other medicines have failed to show significant improvement. It helps to stop cancer growth and further spread and relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipple or changes in the shape or texture of the breast. This medicine is given as an injection by a doctor or nurse. Follow your doctor’s instructions carefully to get the most benefit.

Side effects of Phesgo Solution for Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Phesgo
  • Hair loss
  • Nausea
  • Diarrhea
  • Joint pain
  • Fatigue

How to use Phesgo Solution for Injection

Your doctor or nurse will guide you how to use this medicine.

How Phesgo Solution for Injection works

Phesgo 600mg/600mg Solution for Injection is a combination of two anticancer medicines. Pertuzumab recognizes and attaches to a protein called human epidermal growth factor 2 (HER2). HER2 is abundantly present on the surface of some cancer cells where it stimulates their growth. When pertuzumab attaches to the HER2 cancer cells, it may slow or stop the cancer cells from growing, or may kill them. Trastuzumab binds to HER2 and stops the growth of cancer cells and causes them to die.

Quick tips

  • Do not receive any kind of immunization or vaccination without your doctor’s approval while taking Phesgo 600mg/600mg Solution for Injection.
  • Use contraceptives, and do not conceive a child (get pregnant) while taking Phesgo 600mg/600mg Solution for Injection. Barrier methods of contraception, such as condoms, are recommended.
  • Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.
  • You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your health care provider.
  • To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
  • Take anti-diarrhea medication as prescribed by your doctor and eat foods that may help control diarrhea.
  • Avoid sun exposure. Wear SPF 15 (or higher) sunblock and protective clothing.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Phesgo 600mg/600mg Solution for Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Phesgo 600mg/600mg Solution for Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Phesgo 600mg/600mg Solution for Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving

Driving

UNSAFE
Phesgo 600mg/600mg Solution for Injection may cause side effects which could affect your ability to drive.
It may cause dizziness, chills, fever, or injection or allergic reactions in some people. Do not drive or use machines until these symptoms disappear.
Kidney

Kidney

SAFE IF PRESCRIBED
Phesgo 600mg/600mg Solution for Injection is safe to use in patients with kidney disease. No dose adjustment of Phesgo 600mg/600mg Solution for Injection is recommended.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited information available on the use of Phesgo 600mg/600mg Solution for Injection in patients with liver disease. Please consult your doctor.

Frequently asked questions

Phesgo 600mg/600mg Solution for Injection is given as a loading and maintenance dose. Your first injection is called a loading dose. This dose is given in a large amount once only. For your second and future injections, you have a smaller amount. This is called a maintenance dose. The loading dose is given over 8 minutes and the maintenance dose over 5 minutes.
Phesgo 600mg/600mg Solution for Injection will be given to you by a doctor in a hospital or clinic as an injection under your skin (subcutaneous injection).<br>a. Injections will be given every three weeks.<br>b. You will get the injection first in one thigh and then in the other and this process continuous.<br>c. Your doctor will make sure that each injection is given in a new place (at least 2.5 cm away from any previous place of injection), and where the skin is not red, bruised, tender, or hard.<br>d. Different places for injection should be used for other medicines.
Before the administration of Phesgo 600mg/600mg Solution for Injection let your doctor know if you are allergic to any medicines, or have heart problems, current infection, fever, or diarrhea.
This treatment may harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment and for at least 7 months afterwards. Talk to your doctor about effective contraception before starting the treatment.
Yes, Phesgo 600mg/600mg Solution for Injection may cause severe diarrhea and the risk is more in elderly patients (over 65 years). If you get severe diarrhea during the treatment, your doctor may give you medicines to control it. Your doctor may also stop your treatment with Phesgo 600mg/600mg Solution for Injection until the diarrhea is under control.
Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), oranges, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration. You can also have soups and juices frequently to hydrate yourself.
You can continue with your normal diet unless your doctor tells you otherwise. However, it is advisable to sip water regularly to prevent dehydration, eat small, simple but nourishing snacks every few hours rather than large meals, and suck on hard candy or popsicles to prevent nausea and vomiting.
Nausea and fatigue or tiredness are some of the common side effects of this medicine. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid food that is salty, spicy, fried, or fatty. Take plenty of rest and do light exercise daily to keep yourself active and reduce fatigue.
Yes, while taking this medicine, your hair may become brittle and break. You may also experience patchy hair loss or thinning. These conditions tend to resolve once the treatment is stopped. Be gentle when brushing and washing hair to manage hair loss.
Keep taking this medicine exactly as directed until your doctor tells you to stop. Regular scans will reveal whether your tumor is responding to the treatment or not. Your doctor will determine when those scans should be scheduled.
To relieve constipation, include fiber in your diet (fruits and vegetables), drink 8-10 glasses of fluids a day, and keep active. A stool softener (with a doctor's prescription) once or twice a day may prevent constipation. If you do not have a bowel movement for 2-3 days, consult your doctor.
You may experience a metallic taste or find that food has no taste at all. You may dislike foods or beverages that you liked before receiving cancer treatment. Rinse your mouth with a solution of salt and bicarbonate of soda before mealtimes to neutralize the bad taste in your mouth. You can also add extra flavor or seasonings to your food.
You may experience pain in your joints for a few days after the treatment. If this happens, you can tell your doctor who may prescribe you some painkillers. Never take any over-the-counter painkillers without consulting your doctor while on treatment with Phesgo 600mg/600mg Solution for Injection. You may try the following tips to get relief from joint pain: a. Place a heating pad or covered hot water bottle against the painful area.<br>b. Take warm baths.<br>c. Plan your activities to include regular rests.

Fact Box

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Related lab tests

Breast Cancer (CA 15.3/ ER/ PR)

References

  1. Jagosky M, Tan AR. Combination of Pertuzumab and Trastuzumab in the Treatment of HER2-Positive Early Breast Cancer: A Review of the Emerging Clinical Data. Breast Cancer (Dove Med Press). 2021;13:393-407. [Accessed 24th Nov. 2022] (online) Available from:
  2. Pertuzumab and Trastuzumab [Summary of Product Characteristics]. Grenzach-Wyhlen, Germany: Roche Registration GmbH; 2020. [Accessed 24th Nov. 2022] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Roche Products India Pvt Ltd
Address: 1503, 15th Floor, ‘The Capital’, Plot no. C-70, Behind ICICI Bank, BKC, Bandra (E) , Mumbai 400051

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Phesgo 600mg/600mg Solution for Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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