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Prolia Solution for Injection

Written By Dr. Anuj Saini, MMST, MBBS
Reviewed By Dr. Varun Gupta, MD Pharmacology, MBBS
Last updated on 12 Nov 2024 | 01:01 AM (IST)
Prolia Solution for Injection is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong and reduce the risk of fractures.
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General Information

Contains

Denosumab (60mg)

Marketer

Dr Reddy's Laboratories Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
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Prolia Solution for Injection image
Prolia Solution for Injection image
Prolia Solution for Injection image

Product introduction

Prolia Solution for Injection is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. To make it more effective, take adequate amount of calcium and vitamin D supplements while on treatment with this medicine.

Some common side effects of this medicine include headache, pain in extremity, musculoskeletal pain, nerve pain, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, before taking it, let your doctor know of all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before using this medicine.

Uses of Prolia Solution for Injection

Side effects of Prolia Solution for Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Prolia
  • Rash
  • Musculoskeletal (bone, muscle or joint) pain
  • Eczema
  • Nerve pain
  • Upper respiratory tract infection
  • Sciatica
  • Pain in extremities
  • Headache
  • Back pain
  • Joint pain
  • Urinary tract infection
  • Constipation
  • Abdominal discomfort
  • Hair loss
  • Hypercholesterolemia (high cholesterol)
  • Cystitis

How to use Prolia Solution for Injection

Your doctor or nurse will guide you how to use this medicine.

How Prolia Solution for Injection works

Prolia Solution for Injection is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.

Quick tips

  • Prolia Solution for Injection is a medication used to treat thinning of the bones (called osteoporosis).
  • Take calcium and vitamin D to help build your bones when taking Prolia Solution for Injection.
  • Do not take if you are pregnant or plan to become pregnant.
  • May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
  • Prolia Solution for Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
  • Tell your doctor if you develop a rash while taking Prolia Solution for Injection.
  • Prolia Solution for Injection is a medication used to treat thinning of the bones (called osteoporosis).
  • Take calcium and vitamin D to help build your bones when taking Prolia Solution for Injection.
  • Do not take if you are pregnant or plan to become pregnant.
  • May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
  • Prolia Solution for Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
  • Tell your doctor if you develop a rash while taking Prolia Solution for Injection.

Safety advice

Alcohol

Alcohol

CAUTION
Caution is advised when consuming alcohol with Prolia Solution for Injection. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Prolia Solution for Injection is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Prolia Solution for Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving

Driving

SAFE
Prolia Solution for Injection does not usually affect your ability to drive.
Kidney

Kidney

CAUTION
Prolia Solution for Injection should be used with caution in patients with severe kidney disease. Dose adjustment of Prolia Solution for Injection may be needed. Please consult your doctor.
Liver

Liver

CAUTION
Prolia Solution for Injection should be used with caution in patients with severe liver disease. Dose adjustment of Prolia Solution for Injection may be needed. Please consult your doctor.
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Frequently asked questions

There is no optimal duration of treatment of osteoporosis with Prolia Solution for Injection. The patient’s response and tolerability to the medicine is continuously monitored through periodic assessments, especially after 5 years of use of Prolia Solution for Injection. Depending on this, the duration of taking Prolia Solution for Injection is decided.
Yes, hair loss is a common side effect of Prolia Solution for Injection though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.
Prolia Solution for Injection is not a chemotherapy drug. It is a protein (monoclonal antibody) that interferes with the action of another protein in order to treat bone loss and osteoporosis. Treatment with Prolia Solution for Injection makes the bones stronger and less likely to break.
Prolia Solution for Injection is available as an injection and is given by a healthcare professional. It is given once in 6 months. Your doctor may also advise you to take calcium and vitamin D while taking Prolia Solution for Injection.
No, pregnant women should not take Prolia Solution for Injection. You must use an effective method of birth control during and for at least 5 months after the last dose of Prolia Solution for Injection if you can become pregnant.
Prolia Solution for Injection should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.
Osteonecrosis is a rare side effect of Prolia Solution for Injection. It refers to the damage caused to the bone of jaw. To avoid this, you should maintain good oral hygiene and receive routine dental check ups while taking Prolia Solution for Injection. Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, discharge, pain or swelling, or non-healing of sores. These could be signs of osteonecrosis of jaw.
There is no optimal duration of treatment of osteoporosis with Prolia Solution for Injection. The patient’s response and tolerability to the medicine is continuously monitored through periodic assessments, especially after 5 years of use of Prolia Solution for Injection. Depending on this, the duration of taking Prolia Solution for Injection is decided.
Yes, hair loss is a common side effect of Prolia Solution for Injection though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.
Prolia Solution for Injection is not a chemotherapy drug. It is a protein (monoclonal antibody) that interferes with the action of another protein in order to treat bone loss and osteoporosis. Treatment with Prolia Solution for Injection makes the bones stronger and less likely to break.
Prolia Solution for Injection is available as an injection and is given by a healthcare professional. It is given once in 6 months. Your doctor may also advise you to take calcium and vitamin D while taking Prolia Solution for Injection.
No, pregnant women should not take Prolia Solution for Injection. You must use an effective method of birth control during and for at least 5 months after the last dose of Prolia Solution for Injection if you can become pregnant.
Prolia Solution for Injection should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.
Osteonecrosis is a rare side effect of Prolia Solution for Injection. It refers to the damage caused to the bone of jaw. To avoid this, you should maintain good oral hygiene and receive routine dental check ups while taking Prolia Solution for Injection. Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, discharge, pain or swelling, or non-healing of sores. These could be signs of osteonecrosis of jaw.

Fact Box

Chemical Class

Monoclonal antibody (mAb)

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

Action Class

Bone resorption inhibitors- Monoclonal antibodies

Related lab tests

References

  1. Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
  2. Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
  4. Drugs.com. Denosumab. [Accessed 02 Apr. 2019] (online) Available from:
  5. Denosumab. Milton Road, Cambridge: Amgen Ltd.; 2010 [revised Jun. 2018]. [Accessed 02 Apr. 2019] (online) Available from:
  6. Denosumab [Prescribing Information]. Thousand Oaks, California: Amgen Manufacturing Limited; 2013. [Accessed 20 Feb. 2024] (online) Available from:
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User feedback

Once A Month
85%
Once A Day
10%
Once A Week
5%

Patient concerns

Teriparatide is this injection advisable?

Dr. Akshat Goel
Dr. Akshat Goel
Orthopaedics
Yes, it's good in Osteoporosis

Details About osteoporosis treatment

Dr. Akshat Goel
Dr. Akshat Goel
Orthopaedics
Take Calcium and Vitamin-D3 supplements
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Dr Reddy's Laboratories Ltd
Address: Dr. Reddy's Laboratories Ltd., Village Malpur, P.O.Bhud, Baddi, Dist. Solan, H.P.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Prolia Solution for Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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