Prostium E 0.06% Gel
Written By Dr. Betina Chandolia, MDS, BDS
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology
Last updated on 12 Nov 2024 | 01:06 AM (IST)
Prostium E 0.06% Gel is a female hormone that is identical to estrogen. This is a hormone replacement therapy (HRT) that is used to treat symptoms associated with menopause. This topical preparation helps to treat hot flush, vaginal burning, dryness, and itching cause due to lack of estrogen.
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General Information
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Product introduction
Use Prostium E 0.06% Gel in the exact way as instructed by your doctor or mentioned on the package insert. Do not apply in larger or smaller quantities than recommended. Even if your symptoms improve, you should continue the treatment as it has been prescribed. Do not stop using the medicine until the full course is completed.
The most common side effects of this medicine include headache, flatulence, and breast pain. These usually go away if you continue using it. Tell your doctor if you have bleeding in your vagina. Your doctor may give you an alternative medicine.
Before using this medicine you should tell your doctor if you have unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. Once you have started using this medicine you should have regular check-ups to discuss the benefits of your treatment. It should not interact with any other medicines but it is not usually recommended during pregnancy or breastfeeding.
The most common side effects of this medicine include headache, flatulence, and breast pain. These usually go away if you continue using it. Tell your doctor if you have bleeding in your vagina. Your doctor may give you an alternative medicine.
Before using this medicine you should tell your doctor if you have unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. Once you have started using this medicine you should have regular check-ups to discuss the benefits of your treatment. It should not interact with any other medicines but it is not usually recommended during pregnancy or breastfeeding.
Uses of Prostium E Gel
Benefits of Prostium E Gel
Hormone replacement therapy
Hormone placement therapy (HRT) is a treatment to relieve symptoms of menopause such as hot flushes, vaginal dryness, and reduced sex drive. Since menopause can last for several years, this treatment can make a big improvement to your daily life and mood. Estrogen is one of two important hormones (the other is progesterone) used in this treatment. Vaginal tablets and creams are an easy way to deliver hormones but may not treat all the symptoms. You should use this medicine as it is prescribed, and for as long as it is prescribed by your doctor.
Hormone placement therapy (HRT) is a treatment to relieve symptoms of menopause such as hot flushes, vaginal dryness, and reduced sex drive. Since menopause can last for several years, this treatment can make a big improvement to your daily life and mood. Estrogen is one of two important hormones (the other is progesterone) used in this treatment. Vaginal tablets and creams are an easy way to deliver hormones but may not treat all the symptoms. You should use this medicine as it is prescribed, and for as long as it is prescribed by your doctor.
Side effects of Prostium E Gel
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Prostium E
- Headache
- Breast pain
- Flatulence
How to use Prostium E Gel
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.
How Prostium E Gel works
Prostium E 0.06% Gel contains a medication called estrogen (female sex hormone). It works by replacing estrogen that is normally produced by the body.
All substitutes for Prostium E 0.06% Gel
For information purposes only. Consult a doctor before taking any medicine.
Quick tips
- Prostium E 0.06% Gel is used to relieve vaginal dryness, itching or irritation associated with menopause.
- Use the applicator provided to insert a measured dose of gel into your vagina before going to bed.
- It works locally in the vagina therefore, side effects are rare.
- It may damage condoms and diaphragms and reduce their effectiveness. Use a non-hormonal method of contraception.
Safety advice

Alcohol
No interaction found/established

Pregnancy
CONSULT YOUR DOCTOR
Information regarding the use of Prostium E 0.06% Gel during pregnancy is not available. Please consult your doctor.

Breast feeding
UNSAFE
Prostium E 0.06% Gel is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving
No interaction found/established

Kidney
No interaction found/established

Liver
No interaction found/established
Frequently asked questions
Prostium E 0.06% Gel contains a medicine called Estradiol which is a form of female sex hormone, estrogen. It is used after menopause to reduce moderate to severe hot flushes caused due to lack of estrogen.
Your doctor usually prescribes the lowest possible dose of Prostium E 0.06% Gel. This medicine is applied to an unbroken, clean, and dry skin. Allow the skin to dry completely before covering with a cloth. Wash your hands with soap and water after applying this medicine. Use this medicine only as advised by your doctor. Do not use more than you have been advised.
You may apply the missed dose as soon as you remember unless you are not 12 hours late. If you are more than 12 hours late, then skip the missed dose and follow the usual dosing schedule.
The common side effects of using Prostium E 0.06% Gel are headache, breast pain, and flatulence. If any of these side effects bother you, please consult with your doctor.
Fact Box
Chemical Class
Estradiol Congeners
Habit Forming
No
Therapeutic Class
GYNAECOLOGICAL
Action Class
Estrogens
References
- Levin ER, Hammes SR. Estrogens and Progestins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1173-75.
- Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 701-702.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 500-501.
- Estaradiol. Poland Street, London: Besins Healthcare (UK) Ltd.; 1997 [revised 22 Dec. 2012]. [Accessed 03 Apr. 2019] (online) Available from:
- Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 03 Apr. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 04 Apr. 2019] (online) Available from:
- Estradiol gel [Prescribing Information]. Herndon, VA: ASCEND Therapeutics® US, LLC; 2021. [Accessed 24 June 2023]. (online) Available from:
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Patient concerns
I have been told by doctors I have cystitis also simple cyst in right ovary . What should I be doing its been two years I have this issue
Dr. Megha Gupta
Obstetrics and Gynaecology
Hi PATIENT hormone therapy helps with cysts. Ask your doctor for a hormone replacement.
I am a male to female transsexual and I need Bilateral Orchiectomy at a fair cost I am already on hormone replacement therapy for 2 years anti androgen/spirnolactone (Aldactone) and estrodiol valerate progynova, I need to have bilateral orchiectomy at the cheapest option
Dr. Deepak Kumar Soni
Ayurveda
Hi Kindly consult to your nearest doctor
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Pharmanova India Drugs Pvt Ltd
Address: Old Ct Rd, Palika Bazar, Rani Talab, Jind, Haryana 126102
Address: Old Ct Rd, Palika Bazar, Rani Talab, Jind, Haryana 126102
Vendor Details
Country of origin: India
A licensed vendor partner from your nearest location will deliver Prostium E 0.06% Gel. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
A licensed vendor partner from your nearest location will deliver Prostium E 0.06% Gel. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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