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Retefuse 18mg Injection

Written By Dr. Balshine Singh Kanwar, MD, MBBS
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology
Last updated on 12 Nov 2024 | 01:02 AM (IST)
Retefuse 18mg Injection is a medicine that dissolves clots that have formed in blood vessels. It is used to treat a heart attack. It is known as a thrombolytic or “clot-busting” drug. This medicine restores the blood flow to the affected tissue, thereby preventing tissue death.
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General Information

Contains

Reteplase (18mg)

Marketer

Lupin Ltd

Storage

Store below 30°C
The content is shown in English
Retefuse 18mg Injection image

Product introduction

Retefuse 18mg Injection is an injectable drug, given directly into a vein and it is given by a doctor as soon as possible after the first signs of a heart attack. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely. You may be given another medicine to stop blood clotting at the same time or after the treatment.

This medicine may increase your risk of bleeding, so it is better to be careful while shaving, cutting nails, or using sharp objects. Treatment with this drug can also cause nausea, vomiting, decreased blood pressure, and injection site bleeding.

This drug needs to be administered with care by an expert and is not suitable for everyone. There is a long list of situations where you will not be given Retefuse 18mg Injection including if you have had a head injury or surgery on your brain or spinal cord and any current bleeding anywhere in your body. Your healthcare team will need to know a lot about your medical history before giving you this medicine.

Uses of Retefuse Injection

Benefits of Retefuse Injection

Heart attack
Retefuse 18mg Injection dissolves harmful blood clots that cause heart attack (if they are in the heart). They also dissolve clots that form in other blood vessels. This means that blood can again start to flow freely through your body. This medicine will, therefore, reduce both the damage caused by, and the risk of dying from a heart attack. The sooner the injection is given, the greater are the chances of recovery.

Side effects of Retefuse Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Retefuse
  • Bleeding disorder
  • Nausea
  • Vomiting
  • Decreased blood pressure
  • Injection site bleeding

How to use Retefuse Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Retefuse Injection works

Retefuse 18mg Injection is a thrombolytic medication. It works by dissolving the harmful blood clots in the blood vessels. This restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.

Quick tips

  • It should be given as soon as possible (within 12 hours) after the onset of a heart attack or within 4.5 hours of onset of stroke.
  • Let your doctor know immediately if you develop any nosebleeds, gum bleeding, black or tarry stools, or bruising. 
  • Do not discontinue the medicines started after this injection as it may increase your chances of having another heart attack or stroke.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Retefuse 18mg Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Retefuse 18mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Retefuse 18mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving

Driving

NOT RELEVANT
Not relevant, as Retefuse 18mg Injection is intended for use in hospitalised patients.
Kidney

Kidney

CAUTION
Retefuse 18mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Retefuse 18mg Injection may be needed. Please consult your doctor.
Use of Retefuse 18mg Injection is not recommended in patients with severe kidney disease.
Liver

Liver

CAUTION
Retefuse 18mg Injection should be used with caution in patients with liver disease. Dose adjustment of Retefuse 18mg Injection may be needed. Please consult your doctor.
Use of Retefuse 18mg Injection is not recommended in patients with severe kidney disease.
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Frequently asked questions

Retefuse 18mg Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Retefuse 18mg Injection.
Retefuse 18mg Injection is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.
Yes, Retefuse 18mg Injection can increase the risk of bleeding. Always be careful while doing activities that may cause an injury or bleeding. Tell your doctor immediately if you notice any abnormal bruising or bleeding.
Retefuse 18mg Injection can interact with several medicines. If you are already taking Retefuse 18mg Injection, do not take any other medicine without talking to your doctor.
Retefuse 18mg Injection reduces your risk of developing blood clots in the blood vessels of your leg, lungs, heart and brain. You may not feel any difference after taking Retefuse 18mg Injection. This does not mean that the medicine is not working, therefore keep taking this medicine as prescribed.

Fact Box

Chemical Class

Carboxylic Acids Derivatives

Habit Forming

No

Therapeutic Class

CARDIAC

Action Class

Plasminogen Activators- Thrombolytics

References

  1. Fox KA, White HD, Gersh BJ, et al. Antithrombotic Agents: Platelete Inhibitors, Acute Anticoagulants, Fibrinolytics, and Chronic Anticoagulants. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. p. 384.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1208.
  3. Drugs.com. Reteplase. [Accessed 20 Mar. 2019] (online) Available from:
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User feedback

Heart attack
100%
Average
33%
Excellent
33%
Poor
33%
No Side Effect
100%
With food
100%

Patient concerns

Yesterday got sudden chest pain and sweating heart specialist give retefuse injection We are planning for angiography today We are planning for angiography today ??

Dr. Nabajit Talukdar
Dr. Nabajit Talukdar
Interventional Cardiology
Yes he needs it

Hrert attack home made best treatment

Dr. Spurthi Magdum
Dr. Spurthi Magdum
Ayurveda
Well there is no home remedy for heart attackBut Post - Attack to strengthen the heart you can give Arjuna Ksheerapak
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Lupin Ltd
Address: 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India

Vendor Details

Country of origin: India

Lab tests offered by us

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