Sibofix 400 Tablet

Reviewed By Dr. Shilpa Garcha, MD (Pharmacology), MBBS

Last updated on 12 Nov 2024 | 01:00 AM (IST)

Sibofix 400 Tablet is an antibiotic that treats hepatic encephalopathy, a condition in which the liver fails to remove harmful toxins from the blood, leading to brain damage. It is also used to treat infectious diarrhea. It works by killing and stopping the growth of harmful bacteria in the intestines.

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1/2

10 tablets

General Information

Contains

Rifaximin (400mg)

Marketer

Dr Reddy's Laboratories Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

This medicine can be used alone or in combination with other medicines. It may be taken with or without food, preferably at the same time, each day. It should be used in the dose and duration as advised by the doctor. Take it at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed. Stopping it early may make the infection to come back and harder to treat.

Some people may develop side effects like vomiting, headache, dizziness, nausea, rashes, joint pain, and depression. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or will not go away. Your urine may become reddish in color due to this medicine. But, it is normal and harmless.

Before starting treatment with this medicine, you should tell your doctor if you are pregnant, breastfeeding or suffering from any liver, kidney or heart problems or if you are allergic to any medicine.

Uses of Sibofix Tablet

Treatment of Hepatic encephalopathy
Treatment of Infectious diarrhea

Benefits of Sibofix Tablet

Treatment of Hepatic encephalopathy
Hepatic encephalopathy is a severe liver disease that can cause changes in brain function leading to confusion, tremors (shaking), sleep problems and loss of consciousness. Symptoms include agitation, confusion, muscle problems, difficulty in speaking, and sometimes, coma. Sibofix 400 Tablet lowers the levels of ammonia-producing bacteria in the blood which has harmful effects on the brain. If taken as prescribed, this medicine can improve your brain function and reduce symptoms associated with hepatic encephalopathy.

Treatment of Infectious diarrhea
Infectious diarrhea is a condition characterized by the sudden onset of loose or watery stools caused by harmful microorganisms in the digestive system. Sibofix 400 Tablet helps treat infectious diarrhea by targeting and stopping the growth of harmful bacteria in the intestines. This medicine interferes with the bacteria's ability to make important proteins they need to survive and multiply. This helps to get rid of the bad bacteria causing the infection, which in turn reduces the diarrhea and helps you feel better.

Side effects of Sibofix Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sibofix

Dizziness
Nausea
Peripheral edema
Ascites (accumulation of fluid in the abdominal cavity)
Fatigue
Depression
Nasopharyngitis (inflammation of the throat and nasal passages)
Joint pain
Rash
Muscle pain

How to use Sibofix Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sibofix 400 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Sibofix Tablet works

Sibofix 400 Tablet is an antibiotic. It works by killing the ammonia-producing bacteria in the digestive tract. This treats your infection and relieves symptoms of hepatic encephalopathy (agitation, confusion, muscle problems). This also helps reduce the recurrence of episodes of hepatic encephalopathy.

All substitutes for Sibofix 400 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Sibofix 400 Tablet reduces the risk of overt hepatic encephalopathy (HE) recurrence in patients with liver disease.
It may cause reddish discoloration of urine. This is normal and harmless.
Stop taking Sibofix 400 Tablet and inform your doctor if you have severe diarrhea during or after using Sibofix 400 Tablet.
Finish the full course of the medication, even if you feel better.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Sibofix 400 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Sibofix 400 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Sibofix 400 Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving

SAFE

Sibofix 400 Tablet does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Sibofix 400 Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Sibofix 400 Tablet may not be needed in these patients. Please consult your doctor.

Liver

CAUTION

Sibofix 400 Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Sibofix 400 Tablet may be needed. Please consult your doctor.

Frequently asked questions

Should I take Sibofix 400 Tablet with food?

Yes, Sibofix 400 Tablet can be taken orally with or without food with a glass of water. Take it as prescribed by your doctor for the exact period of time.

What does Sibofix 400 Tablet do for the liver?

In liver disease, there is an increased growth of bacteria in the intestine which increases the load of toxins travelling through the body. This further increases the possibility of toxins reaching the brain which can cause abnormal brain function. Sibofix 400 Tablet slows down the growth of bacteria in the gut, decreasing the symptoms in cases of liver disease.

Can Sibofix 400 Tablet cause weight gain?

Usually Sibofix 400 Tablet does not cause weight gain. However, in case you feel there is an increase in weight, you should consult your doctor to determine the reason of weight gain.

Fact Box

Chemical Class

Rifamycin derivatives

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

RNA polymerase inhibitors- Rifamycins

Related lab tests

Ammonia

Culture Stool

Liver Function Test

Potassium

Sodium

Stool Examination R/M

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1215-16.
Rifaximin [Package Insert]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd.; 2015. [Accessed 05 Aug. 2023] (online) Available from:
CiplaMed. Rifaximin [Prescribing Information]. [Accessed 05 Aug. 2023] (online) Available from:

User feedback

Patients taking Sibofix 400 Tablet

Twice A Day

64%

Thrice A Day

28%

Once A Day

What are you using Sibofix Tablet for?

Hepatic encephalopathy

42%

Diarrhoea

33%

Others

25%

How much was the improvement?

Poor

67%

Average

33%

What were the side-effects while using Sibofix 400 Tablet?

Nausea

100%

Patient concerns

hepatic encephalopathy fro 12 October

Dr. Saurav Arora

Homeopathy

Dear sir as your case is a chronic case it requires long case taking, examination and regular follow up, therefore, please visit a homeopath so that he can examine you and guide you accordingly.

I have diabetes, and I'm taking Glycomet for the same. I was recently hospitalised with a lower respiratory tract infection. The antibiotics I was prescribed gave me diarrhoea. Since the antibiotics course is now over, the doctor has now asked me to take Econorm (twice a day) and Sibofix 400 MG (twice a day). My question is whether I can avoid taking Sibofix, because I am afraid my diarrhoea will restart because Sibofix is an antibiotic. Currently my only problems are lack of appetite and a bloated sensation in my stomach.

Dr. Sanjay Bhatt

Physician

Do proper antibiotics course

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Marketer details

Name: Dr Reddy's Laboratories Ltd
Address: Dr. Reddy's Laboratories Ltd., Village Malpur, P.O.Bhud, Baddi, Dist. Solan, H.P.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Sibofix 400 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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