Yes, Softas Cream may cause local skin reactions like burning, itching, irritation, dryness and hypopigmentation in sensitive individuals, although it is rare. Therefore, it is important to inform your doctor if you have any history of allergy or reaction before you start therapy with this medicine. In some cases, the reason for the allergic reaction could be the added ingredients with the drug. In case of any reaction, stop the medication immediately and inform the doctor.