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Tilstigmin Tablet

Neostigmine (15mg)

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Tilstigmin Tablet is used in the treatment of myasthenia gravis (a disease-causing muscle weakness and tiredness), paralytic ileus (paralysis of intestinal muscles), postoperative urinary retention, and reversal of effect of skeletal muscle relaxants after surgery.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Khushbu Goel, DM, MD,
Last updated on 12 Nov 2024 | 01:00 AM (IST)

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10 tablets

Gurgaon

General Information

Contains

Neostigmine (15mg)

Marketer

Tablets India Limited

Storage

Store below 30°C

The content is shown in English

Product introduction

Tilstigmin Tablet works by reducing and improving muscle weakness. It may be taken with or without food, preferably at the same time each day. Take this medicine in the dose and duration as advised by your doctor. If you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment. You should never stop this medicine suddenly without talking to your doctor.

Some common side effects of using this medication are nausea, vomiting, abdominal cramps, increased production of saliva, and diarrhea. It usually does not cause dizziness and sleepiness. But, if you feel ill, avoid doing any such work that requires focus and attention, such as driving or operating any machinery.

Before taking Tilstigmin Tablet, it is better to inform your doctor if you are suffering from any kidney problems, Parkinson's disease, asthma, or stomach disorders. Your blood pressure may decrease after taking this medicine, so it is better to monitor it and consult your doctor if it bothers you. This medicine may cause diarrhea, so drink plenty of fluids to keep yourself hydrated while taking this medicine. Inform your doctor if you are pregnant, planning to conceive or breastfeeding, before taking this medicine.

Uses of Tilstigmin Tablet

Myasthenia gravis
Paralytic ileus
Post-operative urinary retention
Reversal of effect of skeletal muscle relaxant after surgery

Benefits of Tilstigmin Tablet

Myasthenia gravis
Myasthenia gravis is a neuromuscular disorder that leads to weakness of muscles that are under our control, such as those of the eyes, face, and swallowing. It can result in double vision, drooping eyelids, trouble talking, and trouble walking. It happens due to impaired coordination between muscles and nerves. Tilstigmin Tablet makes this coordination between nerves and muscles better and relieves the symptoms. As a result, your muscle strength is improved and you are able to lead a better life.

Paralytic ileus
Paralytic ileus is the obstruction of the intestines due to improper functioning of the nerves and muscles in the intestine that impairs digestive movement. Tilstigmin Tablet induces contractions in the intestinal muscles and improves their function. As a result, there is better movement of food and this treats the obstruction. Take it as advised by the doctor and follow your doctor’s instructions carefully.

Post-operative urinary retention
After an operation, there may be problems in emptying the bladder. This may be due to disturbed coordination of nerves and muscles of the bladder. Tilstigmin Tablet helps to improve this problem and treats post-operative urinary retention effectively.

Reversal of effect of skeletal muscle relaxant after surgery
Skeletal muscle relaxants are given to induce anesthesia and to carry out surgical or certain diagnostic procedures. This blocks the conduction of signals between nerves and muscles. After the surgery, Tilstigmin Tablet is given to reverse this effect and cause muscle contraction again to restore normal function.

Side effects of Tilstigmin Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Tilstigmin

Nausea
Vomiting
Abdominal cramp
Diarrhea
Increased saliva production

How to use Tilstigmin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tilstigmin Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Tilstigmin Tablet works

Tilstigmin Tablet is a reversible cholinesterase inhibitor. When taken by mouth it increases the level of acetylcholine, a chemical messenger in the brain, by suppressing acetylcholinesterase (enzyme). This acetylcholine further triggers muscle contracting receptors which helps in muscle contraction.

All substitutes for Tilstigmin Tablet

For information purposes only. Consult a doctor before taking any medicine.

Tilistigmin 15mg Tablet

by Tablets India Limited

₹4.98/tablet

2% costlier

Quick tips

You have been prescribed Tilstigmin Tablet for treatment of myasthenia gravis.
It may also be used to treat inactivity of the muscle in the intestines (paralytic ileus) and difficulty in passing urine (urinary retention) after an operation.
Take it as per the dose and duration advised by your doctor. Overdosing can result in extreme muscle weakness.
Do not drink alcohol while taking this medicine as it may worsen the side effects.
Inform your doctor if you have an existing kidney problem, parkinson's disease, asthma, or stomach disorders.

Safety advice

Alcohol

UNSAFE

Tilstigmin Tablet may cause excessive drowsiness with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

Tilstigmin Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Tilstigmin Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Tilstigmin Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney

CAUTION

Tilstigmin Tablet should be used with caution in patients with kidney disease. Dose adjustment of Tilstigmin Tablet may be needed. Please consult your doctor.
Regular monitoring of kidney function test and some blood tests may advised while you are taking this medicine.

Liver

SAFE IF PRESCRIBED

Tilstigmin Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Tilstigmin Tablet may not be needed in these patients. Please consult your doctor.

Frequently asked questions

Does Tilstigmin Tablet treat myasthenia gravis? How long do I need to take it?

Tilstigmin Tablet relieves the symptoms of myasthenia gravis but does not cure it. It does so by reducing and improving muscle weakness. The length of time for which you need to take Tilstigmin Tablet will depend on your condition. Do not stop taking Tilstigmin Tablet until and unless advised by your doctor, even if you start feeling better.

How long does Tilstigmin Tablet take to start working?

Tilstigmin Tablet takes about 5 to 15 minutes to start working and remains effective for 2-4 hours.

Is Tilstigmin Tablet a steroid?

No, Tilstigmin Tablet is not a steroid. It belongs to cholinesterase inhibitor group of medicines. Tilstigmin Tablet work by preventing the breakdown of a chemical called acetylcholine.

Does it cause weight gain?

No, Tilstigmin Tablet does not cause weight gain. Your weight gain may be due to inactivity related to muscle weakness in myasthenia gravis.

Is Tilstigmin Tablet safe to use?

Yes, Tilstigmin Tablet is safe if used in the dose and duration prescribed by the doctor.

I felt better when I started taking Tilstigmin Tablet but I have noticed recently that I get tired easily and quickly. Will increasing the dose help me?

If your symptoms have started reappearing, then it could be due to increased severity of myasthenia gravis or excess dose of Tilstigmin Tablet. Both the conditions have similar effects, so it becomes very difficult to differentiate between the two. Do not increase the dose on your own and consult your doctor immediately.

Can I take Tilstigmin Tablet for constipation?

No, Tilstigmin Tablet should not be taken for any type of constipation. However, its use is limited to cases of constipation caused by paralysis of intestine and strictly on prescription by the doctor.

What should I do if I accidentally take more than the dose required?

You should seek immediate medical help in case of overdose of Tilstigmin Tablet.Excess of Tilstigmin Tablet may cause stomach pain, nausea, vomiting, diarrhea, blurred vision, difficulty in breathing, and excessive sweating, salivation, and weakness. It can even lead to paralysis.

Does Tilstigmin Tablet have any abuse potential?

No, there is no evidence of Tilstigmin Tablet having any abuse potential.

Who should not take Tilstigmin Tablet?

Tilstigmin Tablet should not be taken by patients who are allergic to it. Patients who are constipated or cannot urinate should avoid its use, unless advised by the doctor. This is because Tilstigmin Tablet is only used for certain types of urination problems and constipation (e.g. caused by paralysis of intestine).

Fact Box

Chemical Class

Phenoxy Compounds

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Cholinesterase inhibitors- carbamates

Related lab tests

Acetyl Choline Receptor Antibody

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 969.
Neostigmine bromide. Chippenham, Wiltshire: Alliance Pharmaceuticals; 1995 [revised 15 Jan. 2015]. [Accessed 28 Jan. 2019] (online) Available from:
Neostigmine. Swinton, Manchester: Pharmaserve Limited; 2015]. [Accessed 25 Mar. 2019] (online) Available from:
Drugs.com. Neostigmine Pregnancy and Breastfeeding Warnings. [Accessed 25 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Neostigmine. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:

User feedback

Patients taking Tilstigmin Tablet

Twice A Day

32%

Thrice A Day

30%

Once A Day

29%

Four Times A Day

10%

What are you using Tilstigmin Tablet for?

Myasthenia gravis

90%

Post-operative urinary retention

10%

How much was the improvement?

Poor

43%

Average

33%

Excellent

24%

What were the side-effects while using Tilstigmin Tablet?

No Side Effect

50%

Diarrhoea

25%

Abdominal cramp

25%

How do you take Tilstigmin Tablet?

With or without food

50%

With food

50%

Please rate Tilstigmin Tablet on price

Average

42%

Expensive

42%

Not Expensive

17%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Tablets India Limited
Address: Tablets (India) Limited, “Jhaver Centre”, 72 Marshalls Road, Chennai 600 008.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Tilstigmin Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

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Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945