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Unicalcin 50IU Injection

Written By Dr. Anuj Saini, MMST, MBBS
Reviewed By Dr. Varun Gupta, MD Pharmacology, MBBS
Last updated on 11 Nov 2024 | 01:11 AM (IST)
Unicalcin 50IU Injection is a medicine used in the treatment of postmenopausal osteoporosis. It makes the bones stronger and lowers the risk of fractures. It may also be used to treat Paget’s disease of bone and to quickly reduce calcium levels in the blood.
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General Information

Contains

Calcitonin (Salmon) (50IU)

Marketer

United Biotech Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Unicalcin 50IU Injection image

Product introduction

Unicalcin 50IU Injection is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get the maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. If you stop, your symptoms may get worse.

Some common side effects of this medicine include injection site reactions, flushing, skin rash, fatigue, edema,  musculoskeletal pain, joints pain, high blood pressure, vomiting, abdominal pain, diarrhea, dizziness, headache, and visual disturbance. Talk to your doctor if any of these side effects do not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, before taking this medicine, let your doctor know if you have any problems with your heart, kidneys, or liver. Pregnant and breastfeeding mothers should consult with their doctors before taking the medicine.

Uses of Unicalcin Injection

Benefits of Unicalcin Injection

Post menopausal osteoporosis
Osteoporosis is a common condition that weakens bones, making them fragile and more likely to break. It often occurs in women after menopause. This condition can be treated with bone-strengthening medicines. Unicalcin 50IU Injection slows down the rate at which bone is broken down in your body. This maintains bone density and reduces your risk of breaking a bone. The injection is given by a doctor or nurse and should not be self-administered.
Hypercalcemia
Calcium is a mineral found in different places in your body and has many functions including bone growth. Most of your calcium should be in your bones. When you have more calcium in your blood than normal it is called hypercalcemia. Unicalcin 50IU Injection reduces the amount of calcium in your blood.
Being immobile makes hypercalcemia worse. Whenever possible you should take regular exercise, especially weight-bearing exercise. Do not take calcium or vitamin D3 supplements and try to decrease your intake of these in your diet.
Paget's disease
Paget’s disease is a condition that disrupts the replacement of old bone tissue with new bone tissue. Unicalcin 50IU Injection decreases the bone degeneration and helps in the regeneration of healthy bone tissue. You can help improve the strength of your bones by doing regular exercise (especially weight-bearing exercise), eating healthy foods containing calcium and Vitamin D, and reducing your consumption of alcohol and tobacco. Supplements of calcium and Vitamin D3 are also effective.

Side effects of Unicalcin Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Unicalcin
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • High blood pressure
  • Joint pain
  • Vomiting
  • Dizziness
  • Visual disturbance
  • Edema (swelling)
  • Skin rash
  • Abdominal pain
  • Diarrhea
  • Musculoskeletal (bone, muscle or joint) pain
  • Injection site reactions (pain, swelling, redness)
  • Fatigue
  • Headache

How to use Unicalcin Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Unicalcin Injection works

Unicalcin 50IU Injection is a calcitonin receptor agonist. It acts by suppressing the activity of osteoclasts, cells that cause destruction of bone, thereby strengthening the bones and minimizing the risk of fractures.

Quick tips

  • You have been prescribed Unicalcin 50IU Injection for  short term treatment of paget’s disease, high calcium levels in the blood, and to prevent bone loss in postmenopausal osteoporosis.
  • Treatment is usually done for the shortest possible time with the lowest possible dose.
  • It may cause dizziness, fatigue and blurring of vision. Don't drive or do anything requiring concentration until you know how it affects you.
  • Discontinue Unicalcin 50IU Injection and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.

Safety advice

Alcohol

Alcohol

CAUTION
Caution is advised when consuming alcohol with Unicalcin 50IU Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Unicalcin 50IU Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Unicalcin 50IU Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Unicalcin 50IU Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney

Kidney

CAUTION
Unicalcin 50IU Injection should be used with caution in patients with severe kidney disease. Dose adjustment of Unicalcin 50IU Injection may be needed. Please consult your doctor.
Liver

Liver

SAFE IF PRESCRIBED
Unicalcin 50IU Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Unicalcin 50IU Injection may not be needed in these patients. Please consult your doctor.
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Frequently asked questions

The duration of therapy will depend on the response of the patient towards the therapy and side effects if any encountered during the therapy. Unicalcin 50IU Injection is usually prescribed for a long period in diseases of bone. However, the need for a long and continued therapy has to be assessed from time to time. This is because there are chances of cancer on long-term administration of this medicine.
Unicalcin 50IU Injection contains calcitonin which is a hormone that regulates the calcium level in the blood. This hormone helps the body to reverse bone loss and sometimes also helps in bone formation. Due to this, the number of cells that damage bones becomes comparatively less, hence the bone damage is halted. It has been observed that using Unicalcin 50IU Injection can initially increase bone formation by mild activation of the bone-forming cells.
Calcitriol is the active form of vitamin D and is produced in the kidneys. Calcitriol is also given as a supplement and helps in calcium metabolism in our body. The prime role of calcitriol is to increase the absorption of calcium from the gut, decrease its excretion from the kidneys, and increased deposition of calcium in bones, thereby helping in the maintenance of normal bone health. Whereas, Unicalcin 50IU Injection contains calcitonin which is a hormone that regulates blood calcium levels by excreting the extra calcium from the blood through urine. Both the hormone helps in maintaining the calcium balance in our body.
Unicalcin 50IU Injection is not an analgesic medication that reduces the pain directly. Patients with osteoporosis experience pain in the bone as a common symptom. Unicalcin 50IU Injection is used in osteoporosis for the prevention of bone loss and damage which will indirectly lead to a decrease in the pain perceived by the individual. There are some reports of partial analgesic activity of Unicalcin 50IU Injection, but the fact is yet to be established.
Yes, it is recommended to take an adequate amount of calcium-containing food while you are prescribed Unicalcin 50IU Injection for the treatment of osteoporosis. Also, your prescribing physician may ask you to take calcium and vitamin D supplements if your dietary intake is not enough.

Fact Box

Chemical Class

Hormones

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

Action Class

Bone resorption inhibitors- Calcitonin

Related lab tests

Calcium

Intact Parathyroid Hormone

References

  1. Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 758, 766.
  2. Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1283-84, 1294.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 184-85.
  4. Calcitonin. Stein, Switzerland: Novartis Pharma. [Accessed 02 Apr. 2019] (online) Available from:
  5. Medscape. Calcitonin. [Accessed 02 Apr. 2019] (online) Available from:
  6. Calcitonin-salmon. Stein, Switzerland: Novartis Pharma Stein AG. [Accessed 24 Jan. 2019] (online) Available from:
  7. Calcitonin [Patient Information Sheet]. Surendranagar, Gujarat: Biodeal Laboratories Pvt. Ltd. [Accessed 28 Mar. 2023] (online) Available from:
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Patient concerns

Hi doc, my mom is suffering from right knee pain from past 2yrs. Every thing seems to be normal in x-ray. Want to seek second opinion whether to use UNICALCIN NASAL SPRAY

Dr. Vipul Aggarwal
Dr. Vipul Aggarwal
Orthopaedics
Osteoarthritis is the most common reasonI need to see the X-raysI won't prefer nasal sprayBetter to get dexa scan done and if it's osteoporosis then start with bisphosponates / teriparatide. They are better

I had hot flash, sweating and ganrahat

Dr. Pushkar Mani
Dr. Pushkar Mani
Physician
Seems like post menopausal syndrome. Visit a gynaecologist.
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: United Biotech Pvt Ltd
Address: FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Unicalcin 50IU Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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