Zesnil 50mg Capsule
Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Ashish Ranjan, MD (Pharmacology), MBBS
Last updated on 12 Nov 2024 | 01:09 AM (IST)
Zesnil 50mg Capsule is a prescription medicine used in the treatment of fibromyalgia (a condition in which there are generalized pain and tenderness in the body) and depression. It works by increasing the level of chemical messengers (serotonin and noradrenaline), helping in faster recovery.
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General Information
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Product introduction
Zesnil 50mg Capsule may be taken with or without food. It is advised to take this medicine at a fixed time each day to maintain a consistent level in the blood. If you miss any doses, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. This medication mustn't be stopped suddenly as it may worsen your symptoms.
Some common side effects of this medicine include nausea, vomiting, insomnia (difficulty sleeping), constipation, anxiety, decreased appetite, increased sweating, and sexual dysfunction. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. However, these side effects are temporary and usually resolve on their own in some time. Please consult your doctor if these do not subside or bother you.
Before taking Zesnil 50mg Capsule, inform your doctor if you have any problems with your kidneys, heart, liver, or have a history of seizures (epilepsy or fits). Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or if you have any suicidal thoughts.
Some common side effects of this medicine include nausea, vomiting, insomnia (difficulty sleeping), constipation, anxiety, decreased appetite, increased sweating, and sexual dysfunction. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. However, these side effects are temporary and usually resolve on their own in some time. Please consult your doctor if these do not subside or bother you.
Before taking Zesnil 50mg Capsule, inform your doctor if you have any problems with your kidneys, heart, liver, or have a history of seizures (epilepsy or fits). Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or if you have any suicidal thoughts.
Uses of Zesnil Capsule
Benefits of Zesnil Capsule
Fibromyalgia
Zesnil 50mg Capsule may also be used to treat pain in people with fibromyalgia. It reduces pain and also the mood changes, sleep problems, and tiredness that can be caused by the pain. It interferes with pain messages traveling through the brain. Taking this medicine regularly will have an impact on your overall quality of life. Keep taking the medicine until your doctor advises you to stop.
Zesnil 50mg Capsule may also be used to treat pain in people with fibromyalgia. It reduces pain and also the mood changes, sleep problems, and tiredness that can be caused by the pain. It interferes with pain messages traveling through the brain. Taking this medicine regularly will have an impact on your overall quality of life. Keep taking the medicine until your doctor advises you to stop.
Depression
Zesnil 50mg Capsule helps in maintaining the balance of certain chemicals in the brain that affect mood and behavior. This improves your mood, relieves anxiety, tension, helps you sleep better, and increases your energy levels. Zesnil 50mg Capsule prevents extreme mood changes and helps you feel less agitated. You may experience fewer episodes of depression and low mood.
Zesnil 50mg Capsule helps in maintaining the balance of certain chemicals in the brain that affect mood and behavior. This improves your mood, relieves anxiety, tension, helps you sleep better, and increases your energy levels. Zesnil 50mg Capsule prevents extreme mood changes and helps you feel less agitated. You may experience fewer episodes of depression and low mood.
Side effects of Zesnil Capsule
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zesnil
- Nausea
- Vomiting
- Dizziness
- Insomnia (difficulty in sleeping)
- Constipation
- Anxiety
- Decreased appetite
- Increased sweating
- Sexual dysfunction
How to use Zesnil Capsule
Take this medicine in the dose and duration as advised by your doctor. Zesnil 50mg Capsule may be taken with or without food, but it is better to take it at a fixed time.
How Zesnil Capsule works
Zesnil 50mg Capsule works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.
Quick tips
- It may take 2 to 4 weeks for Zesnil 50mg Capsule to start working. Keep taking it as prescribed.
- It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking Zesnil 50mg Capsule as it may cause excessive drowsiness and increase the risk of liver damage.
- It may cause a sensation of restlessness, especially when you first start taking it. Inform your doctor if this happens to you.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Do not stop taking the medication suddenly without talking to your doctor.
Safety advice

Alcohol
CAUTION
Caution is advised when consuming alcohol with Zesnil 50mg Capsule. Please consult your doctor.

Pregnancy
CONSULT YOUR DOCTOR
Zesnil 50mg Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding
CONSULT YOUR DOCTOR
Zesnil 50mg Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving
UNSAFE
Zesnil 50mg Capsule may cause side effects which could affect your ability to drive.
As Zesnil 50mg Capsule may impair your thinking or reactions and this may affect your ability to drive.
As Zesnil 50mg Capsule may impair your thinking or reactions and this may affect your ability to drive.

Kidney
CAUTION
Zesnil 50mg Capsule should be used with caution in patients with kidney disease. Dose adjustment of Zesnil 50mg Capsule may be needed. Please consult your doctor.

Liver
SAFE IF PRESCRIBED
Zesnil 50mg Capsule is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Zesnil 50mg Capsule may not be needed in these patients. Please consult your doctor.
Caution is advised in patients with the severe liver disease.
Caution is advised in patients with the severe liver disease.

Frequently asked questions
Zesnil 50mg Capsule does not cause addiction
Zesnil 50mg Capsule is not a narcotic
Zesnil 50mg Capsule is a generic and not a controlled substance
Zesnil 50mg Capsule may cause this side effect. Call your doctor if you experience any unusual problems during your treatment.
Fact Box
Chemical Class
Phenylacetamide Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Serotonin-norepinephrine reuptake inhibitors (SNRIs)
References
- Stahl SM, editor. Milnacipran. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 435-39.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 921.
- Milnacipran. New York, New York: Forest Laboratories, Inc.; 2009 [revised Jan. 2009]. [Accessed 25 Mar 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Milnacipran. [Updated 2018 Oct 31]. Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:

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Patient concerns
Hi.I am suffering with lot's of nerves pain only in the right side of the body and also with lot's of dizziness please say me what type of problem do I have. I can't bare it any more.now,I stopped washing cloths.since from 4to5 days
Dr. Vikas Sharma
Neurology
cap duzela 20 mg bd , cud be fibromyalgia
What is a medicine for fibromyalgia?
Dr. Vipul Aggarwal
Orthopaedics
none to be specific
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Marketer details
Name: Consern Pharma Limited
Address: Consern Pharma Private Limited, Kuljive Mahajan(Mg. Director), Rural Focal Point, V.P.O. Tibba, Ludhiana - 141120, Punjab, India
Address: Consern Pharma Private Limited, Kuljive Mahajan(Mg. Director), Rural Focal Point, V.P.O. Tibba, Ludhiana - 141120, Punjab, India
Vendor Details
Country of origin: India
A licensed vendor partner from your nearest location will deliver Zesnil 50mg Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
A licensed vendor partner from your nearest location will deliver Zesnil 50mg Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
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- LFT (Liver Function Test)
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- Uric Acid
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- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hemoglobin
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