Isoniazid + Pyrazinamide + Rifampicin

Written By Dr. Love Sharma

Reviewed By Dr. Varun Gupta

Last updated 25 May 2023 | 06:41 AM (UTC)

Isoniazid + Pyrazinamide + Rifampicin Uses

Isoniazid+Pyrazinamide+Rifampicin is used in the treatment of tuberculosis.

How Isoniazid + Pyrazinamide + Rifampicin works

Isoniazid + Pyrazinamide + Rifampicin is a combination of three medicines: Isoniazid , Pyrazinamide and Rifampicin which treat tuberculosis. Isoniazid prevents the TB bacteria from forming their own protective covering while Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by these bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Pyrazinamide , on the other hand works by slowing the growth of these bacteria.

Common side effects of Isoniazid + Pyrazinamide + Rifampicin

Nausea, Vomiting, Peripheral neuropathy (tingling and numbness of feet and hand), Abdominal pain, Skin rash, Hepatitis (viral infection of liver), Lethargy, Low blood platelets, Thrombocytopenic purpura, Cutaneous reactions

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Medicine brands for Isoniazid + Pyrazinamide + Rifampicin

Macox-ZH

Macleods Pharmaceuticals Pvt Ltd

Shrinivas Gujarat Laboratories Pvt Ltd

Cadila Pharmaceuticals Ltd

Expert advice for Isoniazid + Pyrazinamide + Rifampicin

Isoniazid + Pyrazinamide + Rifampicin should be taken on an empty stomach but at the same time every day.
Do not skip any doses and finish the full course of treatment even if you feel better.
It may cause dizziness. Don't drive or do anything that requires mental focus until you know how Isoniazid + Pyrazinamide + Rifampicin affects you.
Avoid drinking alcohol while taking this medicine as this may increase the risk of side effects on the liver.
Avoid taking hormone-based birth control methods as Isoniazid + Pyrazinamide + Rifampicin may decrease their effectiveness.
Your doctor may monitor your liver function, vision and thyroid function while on treatment with this medicine.