Question 1

What is the difference between Piroxicam and diclofenac?

Accepted Answer

Both Piroxicam and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Piroxicam.

Question 2

What is the difference between Piroxicam and naproxen?

Accepted Answer

Both Piroxicam and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Piroxicam.

Question 3

What is the difference between Piroxicam and meloxicam?

Accepted Answer

Both Piroxicam and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Piroxicam.

Question 4

What is the difference between Piroxicam and ketoprofen?

Accepted Answer

Both Piroxicam and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Piroxicam. Ketoprofen gel also showed excellent tolerability.

Question 5

What is the difference between Piroxicam and tramadol?

Accepted Answer

Piroxicam is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.

Question 6

What is the difference between Piroxicam and nimesulide?

Accepted Answer

Both Piroxicam and nimesulide are pain killers. However, Piroxicam is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.

Question 7

Can Piroxicam be used in the treatment of chikungunya?

Accepted Answer

Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Piroxicam or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Piroxicam.

Question 8

Are Piroxicam and aspirin same?

Accepted Answer

No. Piroxicam and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.

Question 9

Can Piroxicam be used along with dexamethasone?

Accepted Answer

No. Piroxicam should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.

Question 10

Can Piroxicam be used with methocarbamol?

Accepted Answer

Yes. Methocarbamol can be used with Piroxicam as no serious side effects are known. Inform your doctor before starting any of the medication.

Question 11

Can Piroxicam be used along with paracetamol?

Accepted Answer

Yes. Paracetamol can be used with Piroxicam as no serious side effects are known. Inform your doctor before starting any of the medication.

Question 12

Is Piroxicam a NSAID?

Accepted Answer

Yes. Piroxicam is a non-steroidal anti-inflammatory drug (NSAID).

Question 13

Is Piroxicam a sulfa drug?

Accepted Answer

Piroxicam is a sulphur containing compound. Piroxicam can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.

Question 14

Is Piroxicam a blood thinner?

Accepted Answer

No. Piroxicam is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.

Question 15

Is Piroxicam a muscle relaxant?

Accepted Answer

No. Piroxicam is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.

Question 16

Is Piroxicam a narcotic?

Accepted Answer

No. Piroxicam is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.

Question 17

Can Piroxicam be used in hypertension?

Accepted Answer

No. Piroxicam is not a medication to control hypertension. It is important to note that Piroxicam decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Piroxicam.

Question 18

Can Piroxicam be used along with Losartan?

Accepted Answer

No. Piroxicam should not be combined with Losartan. It is important to note that Piroxicam decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Piroxicam.

Question 19

Can Piroxicam be used with Lisinopril?

Accepted Answer

No. Piroxicam should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Piroxicam.

Question 20

Can Piroxicam be used with calcium channel blocker?

Accepted Answer

Yes. Piroxicam can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)

Question 21

Can Piroxicam be used with Tizanidine?

Accepted Answer

Yes, Piroxicam can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.

Question 22

Why is beta cyclodextrin added to Piroxicam?

Accepted Answer

Yes. Piroxicam can be combined with beta-cyclodextrin. Research has shown that combining Piroxicam with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.

Question 23

Are there any alternatives of Piroxicam?

Accepted Answer

Yes. There are alternatives to Piroxicam. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.

Question 24

What are the contraindications for Piroxicam?

Accepted Answer

Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.

Question 25

Can Piroxicam be used in the treatment of allergy?

Accepted Answer

No. Piroxicam is not a drug to treat allergy. It is a pain killer.

Question 26

How long does Piroxicam work?

Accepted Answer

Piroxicam is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.

Question 27

Can you get high by using Piroxicam?

Accepted Answer

No. Piroxicam is not known to cause high. It is a non-narcotic painkiller.

Question 28

Can Piroxicam be used to treat menstrual cramp?

Accepted Answer

Piroxicam is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.

Question 29

Can I use Piroxicam for a migraine?

Accepted Answer

Piroxicam is not approved for the treatment of migraine. Research studies have shown that Piroxicam is effective in significantly decreasing the pain associated with migraine without aura.

Question 30

Is Piroxicam effective in back pain management?

Accepted Answer

Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Piroxicam as the cause of back pain can be different for different person.

Question 31

Is Piroxicam affective in gout management?

Accepted Answer

Yes. Piroxicam can be given for the treatment of acute gout. Research studies have shown Piroxicam to be highly effective in the treatment of acute gout.

Question 32

Can you donate blood when on the medication with Piroxicam?

Accepted Answer

Yes. You can donate blood when on Piroxicam. Do inform your doctor before donating blood.

Question 33

Can I use Piroxicam if I am a diabetic?

Accepted Answer

Piroxicam in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Piroxicam so taking piroxicam can lead to increased risk of renal failure by many folds.

Question 34

Can I use Piroxicam if I have a deranged renal function?

Accepted Answer

No. Piroxicam should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.

Question 35

Can Piroxicam lead to skin reactions?

Accepted Answer

Yes. Piroxicam is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.

Question 36

Can I use Piroxicam if I am pregnant?

Accepted Answer

No. Piroxicam should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.

Question 37

Can I use Piroxicam if I have peptic ulcer disease?

Accepted Answer

No. Piroxicam is contraindicated in cases of active peptic ulcer disease. Piroxicam is known to cause gastric ulceration and bleeding.

Question 38

Can I use Piroxicam if I have asthma?

Accepted Answer

Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs  like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.

Question 39

Can Piroxicam lead to difficulty in conception?

Accepted Answer

Yes. Piroxicam can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.

Question 40

Can Piroxicam be used with diuretics?

Accepted Answer

No. Piroxicam should not be used with diuretics. Piroxicam reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.

Question 41

Can Piroxicam be used with lithium?

Accepted Answer

No. Piroxicam should not be used with lithium. Piroxicam leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.

Question 42

Can Piroxicam be used with warfarin?

Accepted Answer

No. Piroxicam should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.

Question 43

What increases the chances of getting a gastric ulcer when I am already taking Piroxicam?

Accepted Answer

The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.

Question 44

Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Piroxicam?

Accepted Answer

Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.

Question 45

What are the serious side effects of Piroxicam?

Accepted Answer

GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.

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