Ranolazine may cause changes in electrical activity of heart which is known as QT prolongation. Your doctor may get regular tests done to check the electrical activity of your heart. Tell your doctor right away if you feel faint, lightheaded or if your heart starts beating irregularly or fast, as these may be symptoms of QT prolongation. Ranolazine may also cause kidney failure in patients who already have kidney problems. Therefore, your doctor may need to do tests to check how your kidneys are working.

Urine discoloration could be because of Ranolazine. You need not worry if you do not have any other symptoms. However, if it still bothers you, you can talk to your doctor who will advise you further.

Excess of Ranolazine can cause nausea, vomiting, lightheadedness, double vision, tiredness, severe tremor, confusion, hallucinations, difficulty in speaking and walking and you can even faint. If you have taken excess of Ranolazine by mistake, call your doctor right away or seek emergency medical care in a nearby hospital.

Yes, it is safe to take the Ranolazine and Metoprolol together. Ranolazine has minimal effect on blood pressure in patients of angina.

If you are taking metformin along with Ranolazine, you have to be careful since Ranolazine may increase the levels of metformin in the body which can lead to metformin toxicity. Talk to your doctor who will modify the dose of metformin.

It is recommended not to take simvastatin and Ranolazine together because it may cause simvastatin toxicity which may lead to symptoms like muscle weakness and soreness, fatigue, decreased urination, etc. Let your doctor know that you are already taking simvastatin. If it is still necessary to take, then take it exactly as advised by the doctor.