Take adequate water or fluids while taking Topiroxostat to prevent kidney stones.
Treatment with this medicine should not be started during a sudden/severe gout attack. Wait until your current attack is over before starting this medication.
Consult your doctor before taking it if you have or ever had kidney stones, stomach ulcers, peptic ulcers, diabetes, liver disorders or blood disorders.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
Frequently asked questions for Topiroxostat
The usual adult dosage of Topiroxostat is 20 mg/dose orally given twice daily in the morning and evening. Thereafter, the dosage should be gradually increased, as needed, while monitoring blood uric acid levels. The usual maintenance dosage should be 60 mg/dose twice daily. The dose may be adjusted based on the patient’s condition, up to 80 mg/dose twice daily.
Patients with kidney disease should be given Topiroxostat with caution due to the higher risk of side effects in these patients.
The dose of Topiroxostat should be increased gradually, i.e., starting dose should be 20 mg/dose twice daily, and the dose should be increased gradually, for example, to 40 mg/dose twice daily at or after Week 2, and then to 60 mg/dose twice daily at or after Week 6. The patient should be adequately monitored after the dose increase.
Reviewed By Dr. Rajeev Sharma