Anti Phospholipid Antibody IgM

The antiphospholipid antibody IgM test detects the antibodies that bind to phospholipids in the blood. The antiphospholipid antibodies are a group of immune proteins that are produced by the body mistakenly against itself in an autoimmune response to phospholipids. 

Phospholipids are known as structural components of cell membranes. They play an important role in blood clotting. In addition to various coagulation factors, phospholipids are important for the functioning of platelets. 

The antiphospholipid antibodies interfere with the process of clotting and thus posing an affected person to an increased risk of developing recurrent inappropriate blood clots in arteries and veins. This can lead to strokes, heart attacks, or miscarriages. 

The antiphospholipid antibodies are also associated with thrombocytopenia (low platelet counts). Along with that, these antibodies can pose a risk to recurrent miscarriages, especially in the second and third trimester, premature labor, and pre-eclampsia (a complication of pregnancy characterized by high blood pressure). 

The antiphospholipid antibodies have been identified in autoimmune disorders such as lupus, rheumatoid arthritis, and systemic sclerosis. They can also be present in infections like HIV, mononucleosis, and rubella; cancers such as solid tumors, leukemias, lymphomas. The use of certain drugs like procainamide, phenothiazines, and oral contraceptives can also develop antiphospholipid antibodies.