BCR-ABL Qualitative PCR

This test detects the presence or absence of BCR-ABL mRNA transcript in the patient.

BCR-ABL is a fusion gene whose qualitative detection is done in bone marrow or peripheral blood samples. BCR-ABL is an activated protein kinase resulting translocation of long arms of chromosome 9 & chromosome 22 which is also known as Philadelphia chromosome. Philadelphia chromosome is found in both Chronic Myeloid Leukemia and Acute Lymphoid Leukemia. The BCR-ABL gene translocation or t(9;22) is found in more than 95% of CML patients, 5% of pediatric ALL-B CALLA positive, and 15-30% of adult ALL-B CALLA positive patients.