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Creatine Kinase

Creatine Kinase

Also referred as
Creatine Phosphokinase (CPK)
For men & women
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Creatinine Kinase test is used to measure the amount of creatine kinase (CK) in the blood. CK is an enzyme found primarily in the brain, skeletal muscles, and heart. A CK test is usually done in case of muscle weakness and muscle aches. It may also aid in diagnosing a heart attack. Also, a CK test may be advised if a person experiences dark-colored urine for a longer duration of time.

High CK levels can indicate recent muscle damage. Significant increase in CK levels may depend on the severity of muscle damage. Moderately increased CK levels may be due to strenuous exercises such as weight lifting or long exercise sessions.


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What does Creatine Kinase measure?

The Creatine Kinase Test measures the levels of Creatine Kinase in the blood. Creatine Kinase (CK) is an enzyme which is found in the brain, heart, skeletal muscle, and other tissues. In case of muscle damage, increased amounts of CK are released into the blood. 


In the blood, normally small amount of CK is present which comes from the skeletal muscles primarily. In case of any damage to the muscle or interference with the production of muscle, energy can lead to increased levels of CK. Also, these levels may rise if there is any change with the use of muscle energy. The examples of such conditions include strenuous exercise and myositis (inflammation of muscles). 


Muscle diseases (myopathies) such as muscle dystrophy can also lead to an increase in the levels of CK. However, significantly high levels of CK are observed in Rhabdomyolysis which there is an extreme breakdown of skeletal muscle tissue. 


FAQs related to Creatine Kinase

The healthcare provider takes a blood sample from the arm. The site from where the blood is to be withdrawn is cleaned with a swab of rubbing alcohol. This is then followed by inserting a small needle which has a tube attached to it for collecting blood. Once the sufficient blood for analysis is withdrawn, the needle is removed. The site is then covered with a gauze pad.
As such there is no risk but in few cases, bruising, bleeding, and infection at the puncture site can be seen. In very few cases, there can be swelling of the vein after the blood is withdrawn.
The increased levels of creatine kinase can be seen in case of inherited myopathies, such as muscular dystrophy, trauma, burns, electrocution, and compression muscle injuries. Hormonal disorders such as thyroid disorders, Addison’s disease, or Cushing disease and can also increase the levels of creatine kinase in the body. These increased levels can also be the result of strenuous exercise, prolonged surgeries, seizures, viral infections, bacterial infections, parasitic infections, fungal infections, connective tissue disorders such as lupus, rheumatoid arthritis, celiac disease, renal disease, thrombosis. Along with that, the levels of creatine kinase may increase if there is any effect on the production of muscle energy or there is an increase in requirement of energy with the use any medicine.
The rapid breakdown of muscle tissue is known as rhabdomyolysis. It occurs when there is serious physical, chemical, or biological injury to muscles. It may happen due to trauma, crushing injuries, high voltage electrical shock, serious burns, thrombosis, and toxins (e.g., heavy metals, snake venom, and carbon monoxide). Other reasons which can cause rhabdomyolysis include infections, inherited genetic and metabolic disorders affecting muscle, and muscular dystrophy. Conditions like uncontrolled diabetes, hypothyroidism, hyperthyroidism, and drug abuse can equally be a reason for developing rhabdomyolysis.
Content created by
Written by:
Dr. Lipika Khurana
BDS, PGDHHM
Reviewed by:
Dr. Swati Gupta (Anand)
MBBS, MD Lab Medicine
Want to know moreRead our editorial policy
Last Updated17th Mar 2026

Creatine Kinase test price for other cities

Price inAgraRs. 430
Price inAhmedabadRs. 388
Price inAllahabadRs. 388
Price inAmritsarRs. 388
Price inBangaloreRs. 350

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Contains 1 test
Creatine Kinase