
Lipase



The Lipase test is used to determine the level of enzyme lipase made by the pancreas. This test can help diagnose pancreatitis (inflammation in the pancreas), find out any blockage in the pancreas, and pancreas-associated chronic diseases.


Understanding Lipase
Lipase is a digestive enzyme that helps your body digest fat. The pancreas, an organ behind the lower part of your abdomen, produces most lipase. It is also made by your salivary (spit) glands and the stomach, and a small amount is also present in the blood.
If there is a(n) injury/infection/disease, the function of the pancreas can be impaired, which can increase or decrease the production of lipase. An elevated level of lipase may indicate pancreatic diseases like blocked duct or pancreatic cancer, peptic ulcer, gallbladder disease, etc. At the same time, a low level of lipase may be a sign of permanent damage to the pancreatic cells that make lipase. This may happen in certain chronic (long-lasting) diseases, such as cystic fibrosis.
You may need the Lipase test when you experience symptoms such as pain in the upper abdomen that may go to the back, tenderness in the stomach, nausea, pale stool, a full or bloated feeling, jaundice, or the yellowing of the eyes, rapid pulse or heartbeat, and fever. Your doctor may also order this test to check your treatment response. No special preparation is needed for a lipase test. You can eat or drink generally as per your daily routine.
Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The results will help them determine your medical condition, make recommendations for lifestyle modifications such as diet and exercise, decide whether or not medication will be required to manage your condition and formulate an overall treatment plan.
What does Lipase measure?
The Lipase test measures the total amount of lipase enzyme present in the blood. The lipase enzyme breaks down fats (lipids) into smaller molecules. In the gut, it is crucial for digestion, transportation, and the usage of dietary fats and oils. The main source of lipase is the pancreas–the same gland that makes insulin. After a meal, your pancreas releases pancreatic lipase into your digestive tract, where it breaks down triglycerides from fats and oils into smaller molecules like monoglycerides and fatty acids that are easier to absorb. A deranged level of lipase may indicate disease affecting the pancreas.















FAQs related to Lipase
- Lipase [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 31 Jul. 2023]. Available from:
- Kaufman MB. Drug-induced pancreatitis: A Potentially Serious and Underreported Problem. P T. 2013 Jun;38(6):349-51. [Accessed 31 Jul 2023].Available from:
- Klochkov A, Kudaravalli P, Lim Y, et al. Alcoholic Pancreatitis [Internet]. Treasure Island, Florida: StatPearls Publishing; Jan. 2023 [Accessed 31 Jul. 2023]. Available from:
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