Zoladex 3.6 Injection
Written By Dr. Radhika Dua, MDS, BDS
Reviewed By Dr. Shilpa Garcha, MD (Pharmacology), MBBS
Last updated on 12 Nov 2024 | 01:10 AM (IST)
Zoladex 3.6 Injection is used for the treatment of prostate cancer in men and for breast cancer, endometriosis and uterine fibroids in women. In combination with some other medicine, it is used in the treatment of female infertility.
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General Information
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Product introduction
Zoladex 3.6 Injection is given as an injection under the skin by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Hot flashes are a very common side effect of this medicine. It can also cause sexual dysfunction, decreased libido, and urinary tract disorders. The long-term use of medicine may cause weakened bones and a reduction in bone mineral density. You are advised to take vitamin D and calcium supplements while taking this medicine. Women might experience vaginal bleeding during the initials days of treatment, which will stop on its own. Consult with your doctor, if this bothers you or does not go away.
Before taking this medicine, inform your doctor if you have a history of drinking alcohol and diabetes. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Hot flashes are a very common side effect of this medicine. It can also cause sexual dysfunction, decreased libido, and urinary tract disorders. The long-term use of medicine may cause weakened bones and a reduction in bone mineral density. You are advised to take vitamin D and calcium supplements while taking this medicine. Women might experience vaginal bleeding during the initials days of treatment, which will stop on its own. Consult with your doctor, if this bothers you or does not go away.
Before taking this medicine, inform your doctor if you have a history of drinking alcohol and diabetes. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Zoladex Injection
- Prostate cancer
- Endometriosis
- Breast cancer
- Uterine fibroids
- Precocious puberty (premature puberty)
- Female infertility
Benefits of Zoladex Injection
Breast cancer
Zoladex 3.6 Injection relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipple or changes in the shape or texture of the breast. It works by altering the production of those hormones in the body that are essential for the growth and spread of breast cancer. It may also interact with other hormones or have a direct effect on cancer to stop its growth.
Zoladex 3.6 Injection relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipple or changes in the shape or texture of the breast. It works by altering the production of those hormones in the body that are essential for the growth and spread of breast cancer. It may also interact with other hormones or have a direct effect on cancer to stop its growth.
Side effects of Zoladex Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zoladex
- Decreased libido
- Erectile dysfunction
- Depression
- Headache
- Dizziness
- Nausea
- High blood pressure
- Breast atrophy
- Pain during sexual intercourse
- Hot flushes
- Sexual dysfunction
- Urinary tract disorder
- Lethargy
- Pain
- Edema (swelling)
- Upper respiratory tract infection
- Rash
- Sweating
- Decreased appetite
- Chronic obstructive pulmonary disease (COPD)
- Heart failure
- Insomnia (difficulty in sleeping)
- Vaginal inflammation
- Emotional lability
- Acne
- Breast enlargement
- Pelvic discomfort
- Application site reactions (burning, irritation, itching and redness)
- Pain during periods
- Uterine bleeding
How to use Zoladex Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Zoladex Injection works
Zoladex 3.6 Injection is a synthetic hormone. In men, it works by reducing the level of testosterone (male hormone) which causes regression of prostate tumor and improves symptoms. In women, it suppresses the level of estradiol (female hormone) which helps treat advanced breast cancer, endometriosis and uterine fibroids. It also reduces the thickness of the endometrium, which is the uterus lining, prior to surgery.
All substitutes for Zoladex 3.6 Injection
For information purposes only. Consult a doctor before taking any medicine.
Quick tips
- Zoladex 3.6 Injection is used for the treatment of prostate cancer in men and for breast cancer, endometriosis, and uterine fibroids in women.
- It may also be used along with other medicines to treat infertility in women.
- It is a prefilled syringe that is injected under the skin of the abdomen, every 28 days.
- It may cause a reduction in bone mineral density and weakened bones. Your doctor may prescribe other medicines to reduce bone loss.
- Inform your doctor if you start to feel depressed or have disturbing thoughts or feelings during treatment with this medicine.
- Vaginal bleeding may occur in the first month after starting treatment and usually stops on its own. Inform your doctor if bleeding continues.
Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Zoladex 3.6 Injection. Please consult your doctor.

Pregnancy
UNSAFE
Zoladex 3.6 Injection is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding
CONSULT YOUR DOCTOR
Zoladex 3.6 Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving
SAFE
Zoladex 3.6 Injection does not usually affect your ability to drive.

Kidney
SAFE IF PRESCRIBED
Zoladex 3.6 Injection is safe to use in patients with kidney disease. No dose adjustment of Zoladex 3.6 Injection is recommended.

Liver
SAFE IF PRESCRIBED
Zoladex 3.6 Injection is safe to use in patients with liver disease. No dose adjustment of Zoladex 3.6 Injection is recommended.

Fact Box
Chemical Class
GNRH Analogue
Habit Forming
No
Therapeutic Class
HORMONES
Action Class
Gonadotropin-releasing hormone (GnRH) Agonists
Related lab tests
References
- Goserelin acetate. Luton, Bedfordshire: AstraZeneca UK Limited; 2001 [revised 24 Jan. 2017]. [Accessed 26 Mar. 2019] (online) Available from:
- Goserelin acetate implant. Macclesfield, England: AstraZeneca UK Limited; 2009. [Accessed 02 Apr. 2019] (online) Available from:
- UpToDate. Goserelin: Drug information. [Accessed 25 Jun. 2019] (online) Available from:
- OncoLink. Goserelin Acetate. [Accessed 25 Jun. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:

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Patient concerns
My Dr. has given dose of inj. Zoladex 3.6 mg for endometriosis, 3 doses of its are compulsory or 2 doses are sufficient, because I have some side effects like sleeping problem, headache and sickness. Please suggest me.
Dr. Megha Gupta
Obstetrics and Gynaecology
Zoladex is a hormonal treatment. Please cpntinue as prescribed.
Do i have prostrate cancer. Married but now having difficulty in having relation with wife. Penis not hard in the morning. Having problem with self spontaneous erection. Please help. God Bless.
Dr. Sanjay Singh Rai
Medical Oncology and Hematology
Not a symptom of prostate cancer
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: AstraZeneca
Address: Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Address: Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Vendor Details
Country of origin: United kingdom
A licensed vendor partner from your nearest location will deliver Zoladex 3.6 Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
A licensed vendor partner from your nearest location will deliver Zoladex 3.6 Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- Glucose - Postprandial
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid-19 Test (RT-PCR technique)
- LFT (Liver Function Test)
- Kidney Function Test
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid
- Vitamin B12
- C- Reactive Protein Quantitative
- Urine Culture and Sensitivity
- Serum Electrolyte
- Serum Calcium
- Creatinine
- Diabetes Screening
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hemoglobin
- Complete Haemogram
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